ArticleBlood advances2020
Life expectancy and risk factors for early death in patients with severe thalassemia syndromes in South India.
Article in Blood advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Factors Contributing to Improved Bone Mineral Density in Patients With Transfusion-Dependent Thalassemia.The Kaohsiung journal of medical sciences · 2026Article
- Familial Aggregation and Poor Childhood Survival in Thalassemia Despite Early Diagnosis: A Longitudinal Study From Balochistan, Pakistan.Health science reports · 2026Article
- Lymphocyte subsets in untreated thalassemia patients: differences by genotype and age.Frontiers in immunology · 2026Article
- Severe bacterial infection in thalassemia patients: prevalence, predisposing factors, causative organisms and outcomes.Frontiers in medicine · 2026Article
- A standardized extract of Centella asiatica (ECa 233) alleviates brain injury and improves brain function in β-thalassemia mice with iron overload.BMC complementary medicine and therapies · 2025Article
- Short-term risks and benefits of hydroxyurea (hydroxycarbamide)-induced transfusion independence in patients with beta-thalassaemia syndromes.British journal of haematology · 2025Article
- Cost-Benefit Analysis of Genetic Testing as a Prenatal Diagnostic Tool for Thalassemia: A Single-Center Study From Central Thailand.ClinicoEconomics and outcomes research : CEOR · 2025Article
- Survival and causes of death in patients with alpha and beta-thalassemia in Northern Thailand.Annals of medicine · 2024Article
- Knowledge, attitude and acceptance regarding bone marrow transplantation in caregivers of beta-thalassemia major patients.Journal of community genetics · 2024Article
- Beta Thalassemia in Children: Established Approaches, Old Issues, New Non-Curative Therapies, and Perspectives on Healing.Journal of clinical medicine · 2024Review
- Assessment of Serum Vitamin D and Parathyroid Hormone in Children With Beta Thalassemia Major: A Case-Control Study.Cureus · 2024Article
- Long-Term Health-Related Quality of Life and Clinical Outcomes in Patients with β-Thalassemia after Splenectomy.Journal of clinical medicine · 2023Article
- Hematopoietic Stem Cell Transplantation and Results in Pediatric Patients with Thalassemia Major: Single-Center Study.Turkish archives of pediatrics · 2022Article
- Article
- Pulmonary Functions in Transfusion-Dependent Thalassemia.Indian pediatrics · 2022Article
- Right ventricular function in β-thalassemia children: comparing three-dimensional echocardiography with other functional parameters.Pediatric research · 2022Article
- Use of rapid cardiac magnetic resonance imaging to guide chelation therapy in patients with transfusion-dependent thalassaemia in India: UMIMI study.European heart journal. Quality of care & clinical outcomes · 2022Article
- Survival and complications in patients with haemoglobin E thalassaemia in Sri Lanka: a prospective, longitudinal cohort study.The Lancet. Global health · 2022Article
- Multiplex CRISPR/Cas9 genome editing in hematopoietic stem cells for fetal hemoglobin reinduction generates chromosomal translocations.Molecular therapy. Methods & clinical development · 2021Article
- Experience with combination of hydroxyurea and low-dose thalidomide in transfusion-dependent beta thalassemia patients.Annals of hematology · 2021Observational
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22 authors at 4 institutions in 1 country.
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Abstract
In spite of advances in chelation therapy and screening of blood, mortality associated with the most common life-threatening noncommunicable disease of children in India, transfusion-dependent thalassemia (TDT), remains poorly defined. This study aims at estimating death rates and mortality risk factors associated with TDT. The clinical records of 1087 patients from 5 thalassemia centers in India were retrospectively analyzed from 2011 to 2018. Median patient age was 8.5 years, with 107 patients older than 18 years; 656 patients were male and 431 were female. Demographic details and clinical parameters were analyzed at presentation and at last visit. With 41 recorded deaths, actuarial survival at 26.9 years was 50%, and under-5 mortality was 7 times higher than in the general population. Patients with transfusion-transmitted infections (TTIs) had 3.4 times higher risk for death (P = .031). Serum ferritin higher than 4000 ng/dL had 4.6 times higher risk for mortality compared with ferritin lower than 1000 ng/dL (P = .00063). A hemoglobin drop lower than 2 g/dL per week had 7.7 times higher mortality risk compared with a drop of less than 1 g/dL per week (P < .0001). Social determinants (sex, economic status, and distance from center), splenectomy, and even cardiac complications were not associated with higher mortality risk. Main causes of death were infection, iron overload, TTIs, and allo-immunization. Patients who received more than 4 years of adequate care had more than 66% mortality risk reduction (P < .0001). TDT in India continues to result in high mortality. Ineffective transfusion, TTIs, and chelation continue to be the most significant risk factors. Comprehensive care in dedicated day care centers from early age is likely to improve outcomes.
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