ArticlePLoS genetics2020
Conserved nuclear hormone receptors controlling a novel plastic trait target fast-evolving genes expressed in a single cell.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- Practical indistinguishability in a gene regulatory network inference problem, a case study.ArXiv · 2025Article
- Genomic parallelism defines repeated evolution of an inducible offense.Science advances · 2025Article
- Interspecies systems biology links bacterial metabolic pathways to nematode gene expression, chemotaxis behavior, and survival.Genome research · 2025Article
- A NovelBiomolecules · 2025Article
- Functional divergence of conserved developmental plasticity genes between two distantly related nematodes.Scientific reports · 2025Article
- Developmental transcriptomics inGenome research · 2025Article
- EBAX-1/ZSWIM8 destabilizes miRNAs, resulting in transgenerational inheritance of a predatory trait.Science advances · 2025Article
- High Nutritional Conditions Influence Feeding Plasticity in Pristionchus pacificus and Render Worms Non-Predatory.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Review
- Genetic regulators of a resource polyphenism interact to couple predatory morphology and behaviour.Proceedings. Biological sciences · 2024Article
- Starvation resistance in the nematode Pristionchus pacificus requires a conserved supplementary nuclear receptor.Zoological letters · 2024Article
- Nematode genome announcement: A chromosome-scale genome assembly for theJournal of nematology · 2024Article
- Spatial and temporal heterogeneity alter the cost of plasticity in Pristionchus pacificus.PLoS computational biology · 2024Article
- A histone demethylase links the loss of plasticity to nongenetic inheritance and morphological change.Nature communications · 2023Article
- Kin-recognition and predation shape collective behaviors in the cannibalistic nematode Pristionchus pacificus.PLoS genetics · 2023Article
- Co-option of an Astacin Metalloprotease Is Associated with an Evolutionarily Novel Feeding Morphology in a Predatory Nematode.Molecular biology and evolution · 2023Article
- A Mediator subunit imparts robustness to a polyphenism decision.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Divergent combinations of cis-regulatory elements control the evolution of phenotypic plasticity.PLoS biology · 2023Article
- Thousands of Pristionchus pacificus orphan genes were integrated into developmental networks that respond to diverse environmental microbiota.PLoS genetics · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environment shapes development through a phenomenon called developmental plasticity. Deciphering its genetic basis has potential to shed light on the origin of novel traits and adaptation to environmental change. However, molecular studies are scarce, and little is known about molecular mechanisms associated with plasticity. We investigated the gene regulatory network controlling predatory vs. non-predatory dimorphism in the nematode Pristionchus pacificus and found that it consists of genes of extremely different age classes. We isolated mutants in the conserved nuclear hormone receptor nhr-1 with previously unseen phenotypic effects. They disrupt mouth-form determination and result in animals combining features of both wild-type morphs. In contrast, mutants in another conserved nuclear hormone receptor nhr-40 display altered morph ratios, but no intermediate morphology. Despite divergent modes of control, NHR-1 and NHR-40 share transcriptional targets, which encode extracellular proteins that have no orthologs in Caenorhabditis elegans and result from lineage-specific expansions. An array of transcriptional reporters revealed co-expression of all tested targets in the same pharyngeal gland cell. Major morphological changes in this gland cell accompanied the evolution of teeth and predation, linking rapid gene turnover with morphological innovations. Thus, the origin of feeding plasticity involved novelty at the level of genes, cells and behavior.
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