ArticlePLoS computational biology2020
Localized semi-nonnegative matrix factorization (LocaNMF) of widefield calcium imaging data.
Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 86 citations in OpenAlex.
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- Cortex-wide characterization of decision-making neural dynamics during spatial navigation.Nature communications · 2026Article
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- Cortex-Wide Cellular Imaging in Freely Locomoting Mice Using Cortex Camera Array Microscope (CortexCAM).bioRxiv : the preprint server for biology · 2026Article
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- Dynamical Modeling of Behaviorally Relevant Spatiotemporal Patterns in Neural Imaging Data.ArXiv · 2025Article
- Early and widespread cerebellar engagement during hippocampal seizures and interictal discharges.Neurobiology of disease · 2025Article
- Dynamical Modeling of Behaviorally Relevant Spatiotemporal Patterns in Neural Imaging Data.Proceedings of machine learning research · 2025Article
- DeepFace: A High-Precision and Scalable Deep Learning Pipeline for Predicting Large-Scale Brain Activity from Facial Dynamics in Mice.bioRxiv : the preprint server for biology · 2025Article
- Shared-AE: Automatic Identification of Shared Subspaces in High-dimensional Neural and Behavioral Activity.... International Conference on Learning Representations · 2025Article
- Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8).Neurobiology of disease · 2025Article
- Behavioral Classification of Sequential Neural Activity Using Time Varying Recurrent Neural Networks.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025Article
- Nonnegative matrix factorization for analyzing state dependent neuronal network dynamics in calcium recordings.Scientific reports · 2024Article
- Unsupervised pattern identification in spatial gene expression atlas reveals mouse brain regions beyond established ontology.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Wide-field imaging in behaving mice as a tool to study cognitive function.Neurophotonics · 2024Review
- Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8).bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Widefield calcium imaging enables recording of large-scale neural activity across the mouse dorsal cortex. In order to examine the relationship of these neural signals to the resulting behavior, it is critical to demix the recordings into meaningful spatial and temporal components that can be mapped onto well-defined brain regions. However, no current tools satisfactorily extract the activity of the different brain regions in individual mice in a data-driven manner, while taking into account mouse-specific and preparation-specific differences. Here, we introduce Localized semi-Nonnegative Matrix Factorization (LocaNMF), a method that efficiently decomposes widefield video data and allows us to directly compare activity across multiple mice by outputting mouse-specific localized functional regions that are significantly more interpretable than more traditional decomposition techniques. Moreover, it provides a natural subspace to directly compare correlation maps and neural dynamics across different behaviors, mice, and experimental conditions, and enables identification of task- and movement-related brain regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.