ArticleThe journal of trauma and acute care surgery2020
Relationship of body mass index, serum creatine kinase, and acute kidney injury after severe trauma.
Article in The journal of trauma and acute care surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Prevalence and prognostic impact of rhabdomyolysis in adults hospitalized with diabetic ketosis: a 10-year single-center cohort study.Endocrine connections · 2026Article
- The Value of Serum CK in Predicting Traumatic Rhabdomyolysis Induced Acute Kidney Injury: A Systematic Review and Meta-Analysis.Archives of academic emergency medicine · 2026Review
- Decompression only versus decompression plus fusion for spinal canal stenosis of adjacent segment during primary single-segment lumbar fusion surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Effect of Monopolar Electrocautery and Blunt Dissection on Muscle Damage and Inflammation in Patients Undergoing Lumbar Microdiscectomy.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Epidemiology, Risk Factors, and Predictive Modelling of Post-Traumatic Sepsis: A Retrospective Cohort Study.Risk management and healthcare policy · 2025Article
- Retrospective Evaluation of the Severity of Creatine Kinase Elevation in Canine and Feline Trauma Patients as a Predictor of Morbidity and Mortality.Veterinary medicine (Auckland, N.Z.) · 2025Article
- Acute Kidney Injury Post Hip Fracture Surgery: Local Quality Improvement Project and Review of Literature.Cureus · 2024Article
- Therapeutic plasma exchange is feasible and tolerable in severely injured patients with trauma-induced coagulopathy.Trauma surgery & acute care open · 2024Article
- Low preoperative serum fibrinogen level is associated with postoperative acute kidney injury in patients with in acute aortic dissection.Journal of cardiothoracic surgery · 2023Article
- Subcutaneous Adipose Tissue Is Associated with Acute Kidney Injury after Abdominal Trauma Based on the Generalized Propensity Score Approach: A Retrospective Cohort Study.Obesity facts · 2023Article
- Elevated body temperature and leukocyte count are associated with elevated creatine kinase after seizures.Heliyon · 2022Article
- Chest CT Findings and SARS-CoV-2 Infection in Trauma Patients-Is There a Prediction towards Higher Complication Rates?Journal of clinical medicine · 2022Article
- Probabilistic Pairwise Model Comparisons Based on Bootstrap Estimators of the Kullback-Leibler Discrepancy.Entropy (Basel, Switzerland) · 2022Article
- Characteristics of pediatric rhabdomyolysis and the associated risk factors for acute kidney injury: a retrospective multicenter study in Korea.Kidney research and clinical practice · 2021Article
- Acute Kidney Injury following Rhabdomyolysis in Critically Ill Patients.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2021Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectivesBody mass index (BMI) is associated with acute kidney injury (AKI) after trauma, but underlying mechanisms are unclear. Body mass index correlates with both excess adiposity and increased muscle mass. Since the latter could predispose to severe rhabdomyolysis after trauma, we hypothesized that the BMI-AKI association may be partially explained by a direct relationship of BMI with serum creatine kinase (CK).
methodsProspective cohort study of 463 critically ill patients admitted to a level I trauma center from 2005 to 2015 with Injury Severity Score of >15 and serum CK measured in the first 7 days. We defined AKI by AKI Network creatinine criteria. We used simple linear regression to determine the association of BMI with peak CK and multivariable logistic regression to adjust the BMI-AKI association for peak CK and confounders.
resultsMedian age was 43 years, 350 (76%) were male, 366 (79%) had blunt mechanism, and median Injury Severity Score was 24. Body mass index was associated with peak CK (R = 0.05, p < 0.001). Acute kidney injury developed in 148 patients (32%), and median time to peak CK was 29 hours (interquartile range, 15-56 hours) after presentation. Body mass index was significantly associated with AKI in multivariable models adjusted for age, race, sex, diabetes, injury mechanism and severity, and red blood cell transfusions (odds ratio [OR], 1.31 per 5 kg/m; 95% confidence interval [CI], 1.09-1.58; p = 0.004). Adding peak CK to the model partially attenuated the association of BMI with AKI (OR, 1.26 per 5 kg/m; 95% CI, 1.04-1.52; p = 0.018), and peak CK was also associated with AKI (OR, 1.19 per natural log; 95% CI, 1.00-1.41; p = 0.049). Peak CK remained associated with AKI when restricted to patients with values of <5,000 U/L (OR, 1.31 per natural log; 95% CI, 1.01-1.69; p = 0.043).
conclusionSerum CK correlated with BMI and partially attenuated the association of BMI with AKI after major trauma, suggesting that excess muscle injury may contribute to the BMI-AKI association. LEVEL OF EVIDENCE: Epidemiologic study, level III.
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