ArticleEpidemiology (Cambridge, Mass.)2020
The Role of Ambient Particle Radioactivity in Inflammation and Endothelial Function in an Elderly Cohort.
Article in Epidemiology (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exposure to radon and ambient particle radioactivity during pregnancy and adverse maternal, fetal and perinatal outcomes: The current literature and potential mechanisms.Environmental research · 2024Pooled it
- Does protracted radon exposure play a role in the development of dementia?Environmental research · 2022Pooled it
- Updated Knowledge on Radon Exposure: Quantification Methods, Health Effects, and Molecular Mechanisms.Environment & health (Washington, D.C.) · 2026Review
- Source-Specific Radioactivity and Oxidative Potential of Urban PM2.5.Environmental science & technology · 2026Article
- The unique effects of chronic exposure to ambient fine particulate matter and indoor radon on subcortical brain morphology in youth.Neurotoxicology · 2026Article
- Residential radon exposure and incident myocardial infarction and stroke risks in the All of Us Research Program.BMC medicine · 2025Article
- Systematic Review and Meta-Analysis of Inflammatory Biomarkers in Individuals Exposed to Radon.Biomedicines · 2025Review
- Radon Exposure and Gestational Diabetes.JAMA network open · 2025Observational
- Ambient beta particle radioactivity and lung cancer survival: Results from the Boston Lung Cancer Study.Environmental research · 2025Article
- Radon sampling methodologies: A case for accurate, accessible measurements using household instruments.Journal of the Air & Waste Management Association (1995) · 2023Article
- Prenatal Exposure to Ambient Particle Radioactivity and Fetal Growth in Eastern Massachusetts.Air quality, atmosphere, & health · 2023Article
- Dual effects of radiotherapy on tumor microenvironment and its contribution towards the development of resistance to immunotherapy in gastrointestinal and thoracic cancers.Frontiers in cell and developmental biology · 2023Review
- Cumulative effects of air pollution and climate drivers on COVID-19 multiwaves in Bucharest, Romania.Process safety and environmental protection : transactions of the Institution of Chemical Engineers, Part B · 2022Article
- Impacts of exposure to air pollution, radon and climate drivers on the COVID-19 pandemic in Bucharest, Romania: A time series study.Environmental research · 2022Observational
- Associations between solar and geomagnetic activity and peripheral white blood cells in the Normative Aging Study.Environmental research · 2022Article
- The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort.PloS one · 2022Article
- Solar Activity Is Associated With Diastolic and Systolic Blood Pressure in Elderly Adults.Journal of the American Heart Association · 2021Article
- A spatiotemporal ensemble model to predict gross beta particulate radioactivity across the contiguous United States.Environment international · 2021Article
- Unconventional oil and gas development and ambient particle radioactivity.Nature communications · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe mechanisms by which exposure to particulate matter might increase risk of cardiovascular morbidity and mortality are not fully known. However, few existing studies have investigated the potential role of particle radioactivity. Naturally occurring radionuclides attach to particulate matter and continue to release ionizing radiation after inhalation and deposition in the lungs. We hypothesize that exposure to particle radioactivity increases biomarkers of inflammation.
methodsOur repeated-measures study included 752 men in the greater Boston area. We estimated regional particle radioactivity as a daily spatial average of gross beta concentrations from five monitors in the study area. We used linear mixed-effects regression models to estimate short- and medium-term associations between particle radioactivity and biomarkers of inflammation and endothelial dysfunction, with and without adjustment for additional particulate air pollutants.
resultsWe observed associations between particle radioactivity on C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1), but no associations with fibrinogen. An interquartile range width increase in mean 7-day particle radioactivity (1.2 × 10 Bq/m) was associated with a 4.9% increase in CRP (95% CI = 0.077, 9.9), a 2.8% increase in ICAM-1 (95% CI = 1.4, 4.2), and a 4.3% increase in VCAM-1 (95% CI = 2.5, 6.1). The main effects of particle radioactivity remained similar after adjustment in most cases. We also obtained similar effect estimates in a sensitivity analysis applying a robust causal model.
conclusionRegional particle radioactivity is positively associated with inflammatory biomarkers, indicating a potential pathway for radiation-induced cardiovascular effects.
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