Evidence map›Paper›PMID 32282248›Full record

ArticleCirculation2020

Knockout of the Murine Ortholog to the Human 9p21 Coronary Artery Disease Locus Leads to Smooth Muscle Cell Proliferation, Vascular Calcification, and Advanced Atherosclerosis.

Yoko Kojima, Jianqin Ye, Vivek Nanda, Ying Wang, Alyssa M Flores, Kai-Uwe Jarr, Pavlos Tsantilas, Liang Guo, Aloke V Finn, Renu Virmani and 1 more

Open access · greenAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile.Frontiers in cardiovascular medicine · 2022
    Pooled it
  2. Article
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  12. Regulatory Non-coding RNAs in Atherosclerosis.Handbook of experimental pharmacology · 2022
    Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yoko KojimaDepartment of Surgery, Division of Vascular Surgery (Y.K., J.Y., V.N., Y.W., A.M.F., K.-U.J., P.T., N.J.L.), Stanford University School of Medicine, CA.
Jianqin YeDepartment of Surgery, Division of Vascular Surgery (Y.K., J.Y., V.N., Y.W., A.M.F., K.-U.J., P.T., N.J.L.), Stanford University School of Medicine, CA.
Vivek NandaDepartment of Surgery, Division of Vascular Surgery (Y.K., J.Y., V.N., Y.W., A.M.F., K.-U.J., P.T., N.J.L.), Stanford University School of Medicine, CA.
Ying WangDepartment of Surgery, Division of Vascular Surgery (Y.K., J.Y., V.N., Y.W., A.M.F., K.-U.J., P.T., N.J.L.), Stanford University School of Medicine, CA.
Alyssa M FloresDepartment of Surgery, Division of Vascular Surgery (Y.K., J.Y., V.N., Y.W., A.M.F., K.-U.J., P.T., N.J.L.), Stanford University School of Medicine, CA.
Kai-Uwe JarrDepartment of Surgery, Division of Vascular Surgery (Y.K., J.Y., V.N., Y.W., A.M.F., K.-U.J., P.T., N.J.L.), Stanford University School of Medicine, CA.
Pavlos TsantilasDepartment of Surgery, Division of Vascular Surgery (Y.K., J.Y., V.N., Y.W., A.M.F., K.-U.J., P.T., N.J.L.), Stanford University School of Medicine, CA.
Liang GuoCVPath Institute, Gaithersburg, MD (L.G., A.V.F., R.V.).
Aloke V FinnCVPath Institute, Gaithersburg, MD (L.G., A.V.F., R.V.).
Renu VirmaniCVPath Institute, Gaithersburg, MD (L.G., A.V.F., R.V.).
Nicholas J LeeperDepartment of Surgery, Division of Vascular Surgery (Y.K., J.Y., V.N., Y.W., A.M.F., K.-U.J., P.T., N.J.L.), Stanford University School of Medicine, CA.
Stanford University · USCVPath Institute · USCardiovascular Institute of the South · US

Funding

T32 Training Program in Mechanisms and Innovation in Vascular DiseaseT32HL098049 · NHLBI · STANFORD UNIVERSITY · PI Nicholas James Leeper, Philip S Tsao · 2010 to 2026
$6.3M
Clonal expansion, resistance to efferocytosis and innate immunity in atherosclerosisR35HL144475 · NHLBI · STANFORD UNIVERSITY · PI LEEPER, NICHOLAS JAMES · 2019 to 2024
$5.1M
The paradoxical role of CDKN2B in blood vessel sprouting and maturationR01HL125224 · NHLBI · STANFORD UNIVERSITY · PI LEEPER, NICHOLAS JAMES · 2015 to 2018
$1.9M
The role of CDKN2B in efferocytosis and atherosclerosisR01HL123370 · NHLBI · STANFORD UNIVERSITY · PI LEEPER, NICHOLAS JAMES · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL123370NHLBI NIH HHS R01 HL125224NHLBI NIH HHS R35 HL144475NHLBI NIH HHS T32 HL098049
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAtherosclerosisCell ProliferationCoronary Artery DiseaseFemaleHumansMaleMiceMyocytes, Smooth MuscleVascular Calcificationatherosclerosischromosomescoronary artery diseasegeneticsvascular calcification

Identifiers

PMID32282248
PMCPMC7158761
OpenAlexW3003090124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.