Evidence map›Paper›PMID 32281909›Full record

ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Lezanne Ooi, Mirella Dottori, Anthony L Cook, Martin Engel, Vini Gautam, Alexandra Grubman, Damián Hernández, Anna E King, Simon Maksour, Helena Targa Dias Anastacio and 6 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Organoids: a systematic review of ethical issues.Stem cell research & therapy · 2022
    Pooled it
  2. Review
  3. Review
  4. Heliyon · 2024
    Article
  5. Article
  6. Alzheimer's disease induced neurons bearingFrontiers in cellular neuroscience · 2024
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Accelerated neuronal agingFrontiers in aging neuroscience · 2022
    Review
  14. Review
  15. Toward Studying Cognition in a Dish.Trends in cognitive sciences · 2021
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 1 country.

Lezanne OoiIllawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.ORCID 0000-0001-9241-8268
Mirella DottoriIllawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.
Anthony L CookWicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.ORCID 0000-0003-1770-7910
Martin EngelIllawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.ORCID 0000-0001-7602-1340
Vini GautamJohn Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.
Alexandra GrubmanDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Damián HernándezDepartment of Anatomy & Neuroscience, University of Melbourne, Parkville, Victoria, Australia.
Anna E KingWicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.ORCID 0000-0003-1792-0965
Simon MaksourIllawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.
Helena Targa Dias AnastacioIllawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.
Rachelle BalezIllawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.
Alice PébayDepartment of Anatomy & Neuroscience, University of Melbourne, Parkville, Victoria, Australia.
Colin PoutonMonash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Michael ValenzuelaRegenerative Neuroscience Group, Brain and Mind Centre and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Anthony WhiteQueensland Institute of Medical Research Berghofer, Brisbane, Queensland, Australia.
Robert WilliamsonMurdoch Children's Research Institute, Melbourne, Victoria, Australia.
University of Wollongong · AUThe University of Melbourne · AUUniversity of Tasmania · AUAustralian National University · AUAustralian Regenerative Medicine Institute · AUMonash University · AUQIMR Berghofer Medical Research Institute · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a public fascination with cerebral organoids, the "mini-brain," the "brain in a dish". At the same time, the ethical issues around organoids are only now being explored. What are the prospects of using human cerebral organoids to better understand, treat, or prevent dementia? Will human organoids represent an improvement on the current, less-than-satisfactory, animal models? When considering these questions, two major issues arise. One is the general challenge associated with using

Indexed as

Alzheimer DiseaseAnimalsBrainCell DifferentiationDementiaHumansInduced Pluripotent Stem CellsOrganoidsAlzheimer’s diseasecerebralcorticaldementiadisease modelinduced pluripotent stem cellsneurodegenerationorganoids

Identifiers

PMID32281909
PMCPMC7539594
OpenAlexW3015904594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.