Evidence map›Paper›PMID 32281514›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Simulating the effect of cerebral blood flow changes on regional quantification of [

Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Santiago Bullich, Juan D Gispert, Ronald Boellaard, Adriaan A Lammertsma, AMYPAD Consortium

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Evaluation of tau deposition usingAlzheimer's research & therapy · 2022
    Trial
  2. The Role of Amyloid-β and Tau PET in the New Era of Alzheimer Disease Therapies.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Review
  3. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  4. Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  5. Non-invasive quantification ofEJNMMI research · 2024
    Article
  6. Non-invasive quantification ofResearch square · 2023
    Article
  7. Feasibility evaluation of middle-phaseQuantitative imaging in medicine and surgery · 2023
    Article
  8. Article
  9. Quantification of amyloid PET for future clinical use: a state-of-the-art review.European journal of nuclear medicine and molecular imaging · 2022
    Review
  10. Early-phaseScientific reports · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. [EJNMMI research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fiona HeemanAmsterdam UMC, Vrije Universiteit Amsterdam, Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam, Netherlands.ORCID 0000-0001-7769-8329
Maqsood YaqubAmsterdam UMC, Vrije Universiteit Amsterdam, Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam, Netherlands.
Isadora Lopes AlvesAmsterdam UMC, Vrije Universiteit Amsterdam, Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam, Netherlands.
Kerstin HeurlingAntaros Medical AB, Mölndal, Sweden.ORCID 0000-0001-8497-9612
Santiago BullichLife Molecular Imaging GmbH, Berlin, Germany.
Juan D GispertBarcelonaβeta Brain Research Centre, Pasqual Maragall Foundation, Barcelona, Spain.
Ronald BoellaardAmsterdam UMC, Vrije Universiteit Amsterdam, Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam, Netherlands.
Adriaan A LammertsmaAmsterdam UMC, Vrije Universiteit Amsterdam, Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam, Netherlands.
AMYPAD Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Global and regional changes in cerebral blood flow (CBF) can result in biased quantitative estimates of amyloid load by PET imaging. Therefore, the current simulation study assessed effects of these changes on amyloid quantification using a reference tissue approach for [

Indexed as

Alzheimer DiseaseAniline CompoundsBenzothiazolesCase-Control StudiesCerebrovascular CirculationFluorine RadioisotopesHumansPositron-Emission TomographyRadiopharmaceuticalsStilbenes4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbeneAniline CompoundsBenzothiazolesFluorine-18Fluorine RadioisotopesflutemetamolRadiopharmaceuticalsStilbenesAlzheimer’s diseaseamyloid PETcerebral blood flowquantificationsimulation study

Identifiers

PMID32281514
PMCPMC7907983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.