Evidence map›Paper›PMID 32281419›Full record

ArticleAmerican journal of physiology. Renal physiology2020

Western diet induces renal artery endothelial stiffening that is dependent on the epithelial Na

Yuxin Xiong, Annayya R Aroor, Francisco I Ramirez-Perez, Guanghong Jia, Javad Habibi, Camila Manrique-Acevedo, Guido Lastra, Donqqing Chen, Vincent G DeMarco, Luis A Martinez-Lemus and 4 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. The mineralocorticoid receptor in diabetic kidney disease.American journal of physiology. Renal physiology · 2024
    Review
  2. Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet-induced obese male mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  3. Article
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  5. Article
  6. Review
  7. Article
  8. Cystamine reduces vascular stiffness in Western diet-fed female mice.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Yuxin XiongResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri.
Annayya R AroorResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri.
Francisco I Ramirez-PerezDalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri.
Guanghong JiaResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri.
Javad HabibiResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri.
Camila Manrique-AcevedoResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri.
Guido LastraResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri.ORCID 0000-0001-9205-1021
Donqqing ChenResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri.
Vincent G DeMarcoResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri.
Luis A Martinez-LemusResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri.
Michael A HillDalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri.
Frederic JaisserInstitut National de la Santé et de la Recherche Médicale, UMRS 1138, Cordeliers Research Center, Sorbonne University, University Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, Paris, France.
James R SowersResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri.
Adam Whaley-ConnellResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri.
Harry S. Truman Memorial Veterans' Hospital · USUniversity of Missouri · USSecond People's Hospital of Yunnan Province · CNUniversité Paris Cité · FR

Funding

Mineralocorticoid receptor mediates vascular stiffness via dysregulated immunity in perivascular adipose tissueK08HL132012 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LASTRA, GUIDO · 2017 to 2021
$839k
Interactions of the RAAS and a Western Diet on Insulin Metabolic ActionsI01BX001981 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI LASTRA, GUIDO · 2013 to 2022
–
Endothelial Cell Mineralocorticoid Receptor and Tubulointerstitial FibrosisI01BX003391 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI WHALEY CONNELL, ADAM T · 2017 to 2020
–
BLRD VA I01 BX001981BLRD VA I01 BX003391NHLBI NIH HHS K08 HL132012
6 · The paper itself

Abstract

Consumption of a Western diet (WD) induces central aortic stiffening that contributes to the transmittance of pulsatile blood flow to end organs, including the kidney. Our recent work supports that endothelial epithelial Na

Indexed as

Vascular StiffnessAnimalsAortaDiet, WesternElasticityEpithelial Sodium ChannelsFemaleFibrosisMice, Inbred C57BLMice, KnockoutNitric OxideNitric Oxide Synthase Type IIIOxidative StressRenal ArterySignal TransductionVascular DiseasesEpithelial Sodium ChannelsNitric OxideNitric Oxide Synthase Type IIINos3 protein, mouseScnn1a protein, mouseendothelial epithelial Na+ channelendothelial nitric oxide synthaseoxidative stressrenal

Identifiers

PMID32281419
PMCPMC7395479
OpenAlexW3015524318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.