Trial reportJournal of diabetes investigation2020
High serum triglyceride levels in the early first trimester of pregnancy are associated with gestational diabetes mellitus: A prospective cohort study.
Trial report in Journal of diabetes investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Trimester-Specific Serum Lipid Profiles in Gestational Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Maternal metabolic factors and the association with gestational diabetes: A systematic review and meta-analysis.Diabetes/metabolism research and reviews · 2022Pooled it
- Article
- Genetic Insights on Hypertriglyceridaemia-Induced Acute Pancreatitis in Pregnancy: A Case Series and Literature Review.Case reports in endocrinology · 2026Article
- Lipid metabolism-based machine learning models for predicting large for gestational age in non-diabetic pregnancies.Frontiers in endocrinology · 2026Article
- First-trimester biomarkers of gestational diabetes mellitus: A scoping review.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Integrating adipsin with novel cardiometabolic and inflammatory indices for enhanced early prediction of gestational diabetes mellitus: a prospective cohort study.Cardiovascular diabetology · 2025Article
- Effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemia.Scientific reports · 2025Article
- Risk Factors for Gestational Diabetes Mellitus in Mainland China: A Systematic Review and Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Pre-pregnancy LDL/HDL and total Cholesterol/HDL ratios are strong predictors of gestational diabetes mellitus in women undergoing assisted reproductive technologies.Reproductive biology and endocrinology : RB&E · 2024Observational
- Differences in HDL Remodeling during Healthy Pregnancy and Pregnancy with Cardiometabolic Complications.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- First-trimester metabolic profiling of gestational diabetes mellitus: insights into early-onset and late-onset cases compared with healthy controls.Frontiers in molecular biosciences · 2024Article
- Maternal diet quality and associations with plasma lipid profiles and pregnancy-related cardiometabolic health.European journal of nutrition · 2023Article
- Remnant cholesterol, but not other cholesterol parameters, is associated with gestational diabetes mellitus in pregnant women: a prospective cohort study.Journal of translational medicine · 2023Article
- Early pregnancy metabolic syndrome and risk for adverse pregnancy outcomes: findings from Rajarata Pregnancy Cohort (RaPCo) in Sri Lanka.BMC pregnancy and childbirth · 2023Article
- The Association of the Triglyceride and Muscle to Fat Ratio During Early Pregnancy with the Development of Gestational Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Risk prediction models of gestational diabetes mellitus before 16 gestational weeks.BMC pregnancy and childbirth · 2022Article
- Comparison of global definitions of metabolic syndrome in early pregnancy among the Rajarata Pregnancy Cohort participants in Sri Lanka.Scientific reports · 2022Article
- Longitudinal trends in lipid profiles during pregnancy: Association with gestational diabetes mellitus and longitudinal trends in insulin indices.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
AIMS/
introductionPregnant women with gestational diabetes mellitus (GDM) have been reported to have higher serum triglyceride (TG) levels during the entire gestational period. However, whether TGs contribute to the incidence of GDM remains unclear. This study aimed to evaluate whether higher serum TG level during early first trimester is associated with GDM. MATERIALS AND
methodsA prospective single-center cohort study was carried out among pregnant women (n = 2,949) who received regular antenatal care in Fu Xing Hospital, Capital Medical University, Beijing, China. GDM was diagnosed between 24 and 28 gestational weeks. Serum TG levels were measured during gestational weeks 6-8 (TG0) and 16-18 (TG1). TG elevation was the difference between TG1 and TG0.
resultsIn total, 581 pregnant women developed GDM. A 13.1, 18.5 and 28.8% incidence of GDM was observed in women with low, referent and high TG0 levels, respectively. Among women with prepregnancy body mass index <24 kg/m
conclusionHigh TG level during the early first trimester, and TG elevation from the first to early second trimester are associated with GDM development, which persists even after adjusting for confounders.
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