Evidence map›Paper›PMID 32281276›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Cell Engineering with Functional Poly(oxanorbornene) Block Copolymers.

Derek C Church, Jonathan K Pokorski

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Derek C ChurchDepartment of NanoEngineering, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-3815-7471
Jonathan K PokorskiDepartment of NanoEngineering, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-5869-6942

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Protein/Polymer Devices for Slow-Release of Immunotherapies to Treat Ovarian CancerR21EB024874 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POKORSKI, JONATHAN KYLE, STEINMETZ, NICOLE FRANZISKA · 2017 to 2018
$431k
NIBIB NIH HHS R21 EB024874NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Cell-based therapies are gaining prominence in treating a wide variety of diseases and using synthetic polymers to manipulate these cells provides an opportunity to impart function that could not be achieved using solely genetic means. Herein, we describe the utility of functional block copolymers synthesized by ring-opening metathesis polymerization (ROMP) that can insert directly into the cell membrane via the incorporation of long alkyl chains into a short polymer block leading to non-covalent, hydrophobic interactions with the lipid bilayer. Furthermore, we demonstrate that these polymers can be imbued with advanced functionalities. A photosensitizer was incorporated into these polymers to enable spatially controlled cell death by the localized generation of

Indexed as

Cell Engineering3T3 CellsAnimalsCamphanesHumansHydrophobic and Hydrophilic InteractionsJurkat CellsMicePolymerizationPolymersProton Magnetic Resonance SpectroscopyCamphanesPolymersblock copolymerscell-surface engineeringhydrophobic insertionphotosensitizerring-opening metathesis polymerization

Identifiers

PMID32281276
PMCPMC7482174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.