Evidence map›Paper›PMID 32281147›Full record

ReviewMovement disorders : official journal of the Movement Disorder Society2020

A Comprehensive Review of Brain Connectomics and Imaging to Improve Deep Brain Stimulation Outcomes.

Joshua K Wong, Erik H Middlebrooks, Sanjeet S Grewal, Leonardo Almeida, Christopher W Hess, Michael S Okun

Open access · greenAbstract readReview
In one paragraph

Review in Movement disorders : official journal of the Movement Disorder Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Joshua K WongFixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, USA.
Erik H MiddlebrooksDepartment of Radiology, Mayo Clinic, Jacksonville, Florida, USA.
Sanjeet S GrewalDepartment of Neurosurgery, Mayo Clinic, Jacksonville, Florida, USA.
Leonardo AlmeidaFixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, USA.
Christopher W HessFixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, USA.
Michael S OkunFixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, USA.
University of Florida Health · USMayo Clinic in Florida · USUniversity of Florida · USWinnMed · US

Funding

Mobile Decision Support System for Nurse Management of Neuromodulation TherapyR01NR014852 · NINR · UNIVERSITY OF UTAH · PI BUTSON, CHRISTOPHER R, OKUN, MICHAEL S · 2015 to 2019
$2.9M
THE HUMAN THALAMOCORTICAL NETWORK IN TOURETTE SYNDROMER01NS096008 · NINDS · UNIVERSITY OF FLORIDA · PI GUNDUZ, AYSEGUL, OKUN, MICHAEL S · 2016 to 2020
$1.8M
University of Florida R25 Early Research Program for Neurology and Neurosurgery ResidentsR25NS108939 · NINDS · UNIVERSITY OF FLORIDA · PI HOH, BRIAN LIM, HOH, BRIAN LIM · 2019 to 2024
$537k
NINDS NIH HHS R01 NS096008NINDS NIH HHS R25 NS108939NINR NIH HHS R01 NR014852
6 · The paper itself

Abstract

DBS is an effective neuromodulatory therapy that has been applied in various conditions, including PD, essential tremor, dystonia, Tourette syndrome, and other movement disorders. There have also been recent examples of applications in epilepsy, chronic pain, and neuropsychiatric conditions. Innovations in neuroimaging technology have been driving connectomics, an emerging whole-brain network approach to neuroscience. Two rising techniques are functional connectivity profiling and structural connectivity profiling. Functional connectivity profiling explores the operational relationships between multiple regions of the brain with respect to time and stimuli. Structural connectivity profiling approximates physical connections between different brain regions through reconstruction of axonal fibers. Through these techniques, complex relationships can be described in various disease states, such as PD, as well as in response to therapy, such as DBS. These advances have expanded our understanding of human brain function and have provided a partial in vivo glimpse into the underlying brain circuits underpinning movement and other disorders. This comprehensive review will highlight the contemporary concepts in brain connectivity as applied to DBS, as well as introduce emerging considerations in movement disorders. © 2020 International Parkinson and Movement Disorder Society.

Indexed as

ConnectomeDeep Brain StimulationMovement DisordersBrainHumansNeuroimagingconnectivity profileconnectomicsdeep brain stimulationfunctional connectivitystructural connectivity

Identifiers

PMID32281147
PMCPMC7556988
OpenAlexW3015419990

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.