ReviewJournal of assisted reproduction and genetics2020
Mouse embryo assay for human in vitro fertilization quality control: a fresh look.
Review in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Impact of Endometrial Receptivity Analysis on Pregnancy Outcomes In Patients Undergoing Embryo Transfer: A Systematic Review and Meta-Analysis.Journal of assisted reproduction and genetics · 2023Pooled it
- Evaluation of a Novel Fluorescent Marker for Continuous Live Imaging of Preimplantation Embryos.Journal of developmental biology · 2026Article
- Redefining safety standards: a large-scale comparative analysis of bovine versus murine models for medical device embryotoxicity testing.Journal of assisted reproduction and genetics · 2026Article
- From mouse embryo assay to bovine embryo assay: towards an ethical and scientifically superior quality control standard in assisted reproduction technologies.Journal of assisted reproduction and genetics · 2026Review
- The sequential use of IVF disposable devices doesn't cause cumulative toxicity unless a defective device compromises the entire procedure.Scientific reports · 2026Article
- Development and validation of a nomogram integrating endometrial ultrasound parameters to predict clinical pregnancy in frozen-thawed embryo transfer cycles.Frontiers in endocrinology · 2026Article
- Index matching improves the imaging quality of 3D well-of-the-well dishes for embryo culture.Biophotonics discovery · 2026Article
- The Evolution of In Vitro Fertilization Practices in Saudi Arabia: Historical Perspectives and Future Directions.Cureus · 2025Review
- Micro magnetic resonance spectroscopy for noninvasive metabolic screening of mammalian embryos and oocytes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Label-free evaluation of mouse embryo quality using time-lapse bright field and optical coherence microscopy.Communications biology · 2025Article
- Methodological and Ethical Considerations in the Use of Chordate Embryos in Biomedical Research.International journal of molecular sciences · 2025Review
- The severity of meiotic aneuploidy is associated with altered morphokinetic variables of mouse oocyte maturation.Human reproduction open · 2024Article
- Assisted reproductive technology: Short- and long-term outcomes.Developmental medicine and child neurology · 2023Review
- Mineral Oil forArchives of Razi Institute · 2022Review
- Fabrication on the microscale: a two-photon polymerized device for oocyte microinjection.Journal of assisted reproduction and genetics · 2022Article
- Embryo culture media differentially alter DNA methylating enzymes and global DNA methylation in embryos and oocytes.Journal of molecular histology · 2022Article
- Tripronuclear Zygotes in IVF Laboratory Quality Control: Experimental Evaluation and Potential Applications.International journal of general medicine · 2022Article
- Off-gassing plasticware to decrease the toxicity effect in embryo culture.JBRA assisted reproduction · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse embryo assay (MEA) has been used in the field of human in vitro fertilization (IVF) for multiple purposes such as developing embryo culture media, quality control within the laboratory, and procedural training and proficiency testing for embryology staff. In addition, manufacturing companies use the MEA as a means of quality control for the development of embryo culture media and medical devices and to meet the standards of testing for FDA approval of new products. It has long been considered by embryologists and laboratory scientists whether the MEA is an accurate or sensitive test in the quality assessment of culture media and medical devices or if use of this testing is more an obligation. There is no uniformly accepted gold standard method for IVF lab quality control or FDA approval. This review aims to revisit the role of the use of mouse embryos in the formulation of IVF media for clinical use and the different methods of employing the mouse embryo assay for quality control. In addition, we will review the use of the MEA as an important adjunct in the training for embryology staff and fellows in training in reproductive endocrinology and infertility (REI), as well as alternatives to the use of the MEA for these purposes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.