ArticleKidney international reports2020
Prediction of Short- and Long-Term Outcomes in Childhood Nephrotic Syndrome.
Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 67 citations in OpenAlex.
- Steroid-sparing drugs in children and young adults with nephrotic syndrome: a target trial emulation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Trial
- Anti-nephrin antibodies in pediatric nephrotic syndrome: a new paradigm.Pediatric nephrology (Berlin, Germany) · 2026Review
- Impact of childhood and parental smoking and substance use on nephrotic syndrome outcomes: a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Machine learning prediction of childhood nephrotic syndrome outcomes.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Single relapse at ≥ 0.5 mg/kg alternate-day prednisone predicts course of childhood nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Persistent Haematuria Is Associated With Reduced Kidney Survival in Primary Podocytopathies.Nephrology (Carlton, Vic.) · 2026Article
- Efficacy and safety of scheduled rituximab in children with refractory nephrotic syndrome after multi-target therapy failure.Pediatric nephrology (Berlin, Germany) · 2026Article
- Authors' Reply: Characterization of Spontaneous Treatment Free Remission in Relapsing Childhood Steroid Sensitive Nephrotic Syndrome.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Establishing core outcomes and minimal clinically important differences for childhood steroid sensitive nephrotic syndrome clinical trials: results from a Delphi consensus process.Pediatric nephrology (Berlin, Germany) · 2026Article
- When Minimal Becomes Massive: A Case Report of Childhood-Onset Minimal Change Disease Marching to End Stage Renal Disease Despite Modern Immunotherapy.Clinical medicine insights. Case reports · 2026Article
- Association between cytokine levels and disease relapse in newly diagnosed childhood-onset primary nephrotic syndrome.Frontiers in pediatrics · 2026Article
- Predictors of time to remission in children with steroid-sensitive nephrotic syndrome: a prospective observational study in Nepal.BMC nephrology · 2025Observational
- Steroid response and outcomes in childhood nephrotic syndrome: A multicenter, cross-sectional study from Jordan.World journal of clinical pediatrics · 2025Article
- Challenging Clinical Practice Guideline Definitions in Childhood Nephrotic Syndrome.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Machine learning using serial changes in proteinuria during initial steroid therapy to predict treatment response and immunosuppressant use in pediatric idiopathic nephrotic syndrome.Clinical and experimental nephrology · 2025Article
- Childhood idiopathic nephrotic syndrome: recent advancements shaping future guidelines.Pediatric nephrology (Berlin, Germany) · 2025Review
- Serum Syndecan-1 is Associated With Kidney and Cardiovascular Outcomes in Idiopathic Nephrotic Syndrome.Kidney international reports · 2025Article
- Management of Nephrotic Syndrome in Pediatric Patients Treated by Different Steroid Regimens.Medicina (Kaunas, Lithuania) · 2025Article
- Prolonged remission after cyclophosphamide or tacrolimus treatment in childhood nephrotic syndrome: a cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Single (375 mg/mPediatric nephrology (Berlin, Germany) · 2025Article
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIt is unknown whether steroid sensitivity and other putative risk factors collected at baseline can predict the disease course of idiopathic nephrotic syndrome in childhood. We determined whether demographic, clinical, and family reported factors at presentation can predict outcomes in idiopathic nephrotic syndrome.
methodsAn observational cohort of 631 children aged 1 to 18 years diagnosed with idiopathic nephrotic syndrome between 1993 and 2016 were followed up until clinic discharge, 18 years of age, end-stage kidney disease (ESKD), or the last clinic visit. Baseline characteristics were age, sex, ethnicity, and initial steroid sensitivity. Of these, 287 (38%) children also reported any family history of kidney disease, preceding infection, microscopic hematuria, and history of asthma/allergies. The outcomes were complete remission after initial steroid course, need for a second-line agent, frequently relapsing disease, and long-term remission. The discriminatory power of the models was described using the c-statistic.
resultsOverall, 25.7% of children had no further disease after their initial steroid course. In addition, 31.2% developed frequently relapsing disease; however, 77.7% were disease-free at 18 years of age. Furthermore, 1% of children progressed to ESKD. Logistic regression modeling using the different baseline exposures did not significantly improve the prediction of outcomes relative to the observed frequencies (maximum c-statistic, 0.63; 95% confidence interval [CI], 0.59-0.67). The addition of steroid sensitivity did not improve outcome prediction of long-term outcomes (c-statistic, 0.63; 95% CI, 0.54-0.70).
conclusionsDemographic, clinical, and family reported characteristics, specifically steroid sensitivity, are not useful in predicting relapse rates or long-term remission in idiopathic nephrotic syndrome. Further studies are needed to address factors that contribute to long-term health.
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