Evidence map›Paper›PMID 32280839›Full record

ArticleKidney international reports2020

Urinary Epidermal Growth Factor as a Marker of Disease Progression in Children With Nephrotic Syndrome.

Debbie S Gipson, Howard Trachtman, Anne Waldo, Keisha L Gibson, Sean Eddy, Katherine M Dell, Tarak Srivastava, Kevin V Lemley, Larry A Greenbaum, Sangeeta Hingorani and 18 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
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  5. Article
  6. Article
  7. Article
  8. Observational
  9. Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulonephropathy Network.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
    Observational
  10. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 16 institutions in 1 country.

Debbie S GipsonDivision of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Howard TrachtmanDivision of Nephrology, Department of Pediatrics, New York University Langone Health, New York, New York, USA.
Anne WaldoDivision of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Keisha L GibsonUniversity of North Carolina Kidney Center at Chapel Hill, Chapel Hill, North Carolina, USA.
Sean EddyDivision of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Katherine M DellDepartment of Pediatrics, Case Western Reserve University, Cleveland Clinic Children's, Cleveland, Ohio, USA.
Tarak SrivastavaSection of Nephrology, Children's Mercy Hospital and University of Missouri at Kansas City, Kansas City, Missouri, USA.
Kevin V LemleyDivision of Nephrology, Children's Hospital-LA, Los Angeles, California, USA.
Larry A GreenbaumDivision of Pediatric Nephrology, Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Sangeeta HingoraniDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
Kevin E MeyersDivision of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Frederick J KaskelDivision of Nephrology, Department of Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, New York, New York, USA.
Kimberly J ReidyDivision of Nephrology, Department of Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, New York, New York, USA.
Christine B SethnaPediatric Nephrology, Cohen Children's Medical Center of New York, Zucker School of Medicine, Hofstra University, Hempstead, New York, USA.
Cheryl L TranDepartment of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
Chia-Shi WangDivision of Pediatric Nephrology, Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Katherine R TuttleProvidence St. Joseph Health, Providence Medical Research Center, Spokane, Washington, USA.
Gia OhDivision of Nephrology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Alicia M NeuDivision of Pediatric Nephrology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Elizabeth BrownDivision of Nephrology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas, USA.
Jen-Jar LinDivision of Pediatric Nephrology, Brenner Children's Hospital, Wake Forest University Baptist Health, Winston-Salem, North Carolina, USA.
Jennifer Lai YeeDivision of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Therese M RothDivision of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Jonathan P TroostDivision of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Brenda W GillespieDivision of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Matthew G SampsonDivision of Nephrology, Boston Children's Hospital, Boston, Massachusetts, USA.
Matthias KretzlerDivision of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Wenjun JuDivision of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan–Ann Arbor · USAlbert Einstein College of Medicine · USEmory University · USUniversity of Washington · USAtrium Health Wake Forest Baptist · USBoston Children's Hospital · USCase Western Reserve University · USChildren's Hospital of Los Angeles · USChildren's Hospital of Philadelphia · USChildren's Mercy Hospital · USCohen Children's Medical Center · USJohns Hopkins Medicine · USMayo Clinic · USNYU Langone Health · USSouthwestern Medical Center · USStanford University · US

Funding

Training Program in Clinical & Translationa Research in Human Glomerular DiseaseU54DK083912 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GIPSON, DEBBIE S · 2009 to 2023
$20.3M
University of Michigan O'Brien Kidney Translational Core CenterP30DK081943 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PENNATHUR, SUBRAMANIAM · 2008 to 2022
$12.9M
A Novel Mobile Application for Childhood Nephrotic Syndrome ManagementK23DK118189 · NIDDK · EMORY UNIVERSITY · PI WANG, CHIA-SHI · 2019 to 2023
$941k
NIDDK NIH HHS K23 DK118189NIDDK NIH HHS P30 DK081943NIDDK NIH HHS U54 DK083912
6 · The paper itself

Abstract

introductionChildhood-onset nephrotic syndrome has a variable clinical course. Improved predictive markers of long-term outcomes in children with nephrotic syndrome are needed. This study tests the association between baseline urinary epidermal growth factor (uEGF) excretion and longitudinal kidney function in children with nephrotic syndrome.

methodsThe study evaluated 191 participants younger than 18 years enrolled in the Nephrotic Syndrome Study Network, including 118 with their first clinically indicated kidney biopsy (68 minimal change disease; 50 focal segmental glomerulosclerosis) and 73 with incident nephrotic syndrome without a biopsy. uEGF was measured at baseline for all participants and normalized by the urine creatinine (Cr) concentration. Renal epidermal growth factor (EGF) mRNA was measured in the tubular compartment microdissected from kidney biopsy cores from a subset of patients. Linear mixed models were used to test if baseline uEGF/Cr and EGF mRNA expression were associated with change in estimated glomerular filtration rate (eGFR) over time.

resultsHigher uEGF/Cr at baseline was associated with slower eGFR decline during follow-up (median follow-up = 30 months). Halving of uEGF/Cr was associated with a decrease in eGFR slope of 2.0 ml/min per 1.73 m

conclusionuEGF/Cr may be a useful noninvasive biomarker that can assist in predicting the long-term course of kidney function in children with incident nephrotic syndrome.

Indexed as

disease progressionepidermal growth factorfocal segmental glomerulosclerosisnephrotic syndromepediatrics

Identifiers

PMID32280839
PMCPMC7136430
OpenAlexW2992466611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.