ReviewHeliyon2020
Biological molecules in dental applications: hyaluronic acid as a companion biomaterial for diverse dental applications.
Review in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06324474 (Clinical and Immunological Evaluation of Hyaluronic Acid Topical Application in Non-surgical Treatment of Periodontitis), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Immunological Evaluation of Hyaluronic Acid Topical Application in Non-surgical Treatment of Periodontitis
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Hyaluronic acid efficacy in root coverage procedures: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Exploring topical atorvastatin hyalurosomal gel as an adjuvant for reducing systemic corticosteroid dosage: a randomized clinical trial in severe oral lichen planus patients.Drug delivery and translational research · 2026Trial
- Autogenous Demineralized Dentin Graft With High Molecular Weight Hyaluronic Acid in Ridge Preservation: Pilot Trial.Clinical implant dentistry and related research · 2025Trial
- Efficacy of an experimental toothpaste containing sodium bicarbonate, sodium hyaluronate and sodium fluoride on gingivitis.BMC oral health · 2024Trial
- Trial
- Article
- The Use of Hyaluronic Acid in the Non-Surgical Treatment of Periodontitis-An Umbrella Review.Biomedicines · 2025Review
- Multiple Recessions Coverage Using the Modified Tunnel Technique and Connective Tissue Graft with or Without Cross-Linked Hyaluronic Acid: 2-Year Outcomes of RCT.Journal of functional biomaterials · 2025Article
- Engineered collagen XVII-loaded dissolving microneedle patch for promoting hair regrowth in androgenic alopecia.Regenerative biomaterials · 2025Article
- A Three-Month Clinical Trial on the Efficacy of Hyaluronic Acid Adjunctive Non-Surgical Therapy for Periodontitis in Patients with Type 2 Diabetes Mellitus.Biomedicines · 2024Article
- Hyaluronic Acid in Bone Regeneration: Systematic Review and Meta-Analysis.Dentistry journal · 2024Review
- Article
- Article
- Evaluation of Cytotoxicity of Hyaluronic Acid/Chitosan/Bacterial Cellulose-Based Membrane.Materials (Basel, Switzerland) · 2023Article
- Article
- Unilateral hard palate necrosis following gingival injections with hyaluronic acid.BMJ case reports · 2023Article
- Effectiveness of hyaluronic acid in the management of oral lichen planus: a systematic review and meta-analysis.Journal of dental anesthesia and pain medicine · 2022Review
- Article
- Cells and material-based strategies for regenerative endodontics.Bioactive materials · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe application of hyaluronic acid (HA) in dental treatments is relatively new, and modified-HA products can be vastly different from each other. This study aims to provide a basis for bridging specific characteristics of HA with its potential applications in dental treatments, evaluating and comparing different types of HA products and for future research on HA applications in dentistry. DATA SOURCES: Information from the existing literature on HA applications has been cited. STUDY SELECTION: Furthermore, this study is specifically oriented to provide oral health care providers with a scientific basis for HA use along with the clinical aspects of HA.
conclusionsOutcomes from existing and future studies cannot be generalised for HA use in dental applications. Therefore, we have proposed a scheme to bridge HA specific characteristics to its applications in dental treatments and compare different HA products used for the same clinical application to identify the most suitable one. CLINICAL SIGNIFICANCE: Highlighting the use of HA in dental treatments and providing a basis for developing new methods, protocols, and products specifically oriented for dentistry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.