ArticleBioMed research international2020
Optimized Cylindrical Diffuser Powers for Interstitial PDT Breast Cancer Treatment Planning: A Simulation Study.
Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Quantitative investigations on light emission profiles for interstitial laser treatment.Biomedical optics express · 2024Article
- Recent advances in innovative strategies for enhanced cancer photodynamic therapy.Theranostics · 2021Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIt is well known that interstitial photodynamic therapy (iPDT) of large tumors requires effective planning to ensure efficient delivery of therapeutic dose to the target tumors. This should be achieved in parallel with minimal damage to the nearby intact tissues. To that end, clinical iPDT can be attained using cylindrical diffusing optical fibers (CDFs) as light sources. In this work, we optimize output CDF powers in order to deliver a prescribed light dose to a spherical volume such as a tumor node.
methodsFour CDFs are placed vertically inside the tumor node. The fluence rate is calculated using the diffusion equation. Therapeutic target dose is (20-50) J·cm
resultsFor four CDFs, the therapeutic target dose (20-50) J·cm
conclusionOptimizing delivered powers enables the distribution of the therapeutic dose uniformly in the medium. In addition, this simulation study represents an essential part of a development dosimetry system for measuring and controlling the optical dose in the breast tumors.
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