ArticleBioMed research international2020
Brain Cortical Complexity Alteration in Amyotrophic Lateral Sclerosis: A Preliminary Fractal Dimensionality Study.
Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cortical complexity estimation using fractal dimension: A systematic review of the literature on clinical and nonclinical samples.The European journal of neuroscience · 2022Pooled it
- Brain structural morphometry in non-musicians with superior pitch identification ability.Scientific reports · 2026Article
- Brain Folding Trajectories in Amyotrophic Lateral Sclerosis.Human brain mapping · 2026Article
- Alterations in cortical surface morphometry in fibromyalgia: a multi-parametric study.Frontiers in psychology · 2026Article
- Sensory Dysfunction in ALS and Other Motor Neuron Diseases: Clinical Relevance, Histopathology, Neurophysiology, and Insights from Neuroimaging.Biomedicines · 2025Review
- Sex-specific brain morphological and network differences in patients showing Parkinson's disease with and without possible rapid eye movement sleep behavior disorder.Frontiers in neurology · 2025Article
- Differences in structural brain morphometry between musicians and non-musicians.Frontiers in human neuroscience · 2025Article
- Abnormal topological structure of structural covariance networks based on fractal dimension in noise induced hearing loss.Scientific reports · 2024Article
- Structural brain morphometry differences and similarities between young patients with Crohn's disease in remission and healthy young and old controls.Frontiers in neuroscience · 2024Article
- Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes.Neurobiology of aging · 2023Article
- Corticospinal fibers with different origins impair in amyotrophic lateral sclerosis: A neurite orientation dispersion and density imaging study.CNS neuroscience & therapeutics · 2023Article
- Cortical complexity in world trade center responders with chronic posttraumatic stress disorder.Translational psychiatry · 2021Article
- Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson's Disease in Early-Stage.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFractal dimensionality (FD) analysis provides a quantitative description of brain structural complexity. The application of FD analysis has provided evidence of amyotrophic lateral sclerosis- (ALS-) related white matter degeneration. This study is aimed at evaluating, for the first time, FD alterations in a gray matter in ALS and determining its association with clinical parameters.
resultsALS patients showed decreased FD values in the left precentral gyrus and central sulcus, left circular sulcus of insula (superior segment), left cingulate gyrus and sulcus (middle-posterior part), right precentral gyrus, and right postcentral gyrus. The FD values in the right precentral gyrus were positively correlated to ALSFRS-R scores (
conclusionsOur results suggest an ALS-related reduction in structural complexity involving the gray matter. FD analysis may shed more light on the pathophysiology of ALS.
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