Evidence map›Paper›PMID 32280620›Full record

ArticleAnesthesiology and pain medicine2019

Effect of Low-Dose Intravenous Ketamine on Prevention of Headache After Spinal Anesthesia in Patients Undergoing Elective Cesarean Section: A Double-Blind Clinical Trial Study.

Amirsadra Zangouei, Seyed Ali Hossein Zahraei, Amir Sabertanha, Ali Nademi, Zahra Golafshan, Malihe Zangoue

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anesthesiology and pain medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  14. Ketamine as Adjuvant for Acute Pain Management.Anesthesiology and pain medicine · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Amirsadra ZangoueiStudent Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyed Ali Hossein ZahraeiStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Amir SabertanhaDepartment of Anesthesiology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Ali NademiStudent Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Zahra GolafshanStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Malihe ZangoueDepartment of Anesthesiology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Birjand University of Medical Sciences · IRShiraz University of Medical Sciences · IRMashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpinal anesthesia is the most commonly used method for elective cesarean section, which is a popular technique due to its simplicity, reliability, and speed to achieve adequate anesthesia. Headache following dura perforation is the most important delayed complication following spinal and epidural anesthesia.

objectivesTo evaluate the impact of low-dose intravenous ketamine in patients undergoing cesarean section under spinal anesthesia on the prevention of dura perforation headache (PDPH).

methodsThis clinical trial study was performed on 64 pregnant women undergoing cesarean section at Vali-e-Asr Hospital. The patients were divided into two groups. In the case group, 0.15 mg/kg body weight ketamine was injected intravenously and in the control group, normal saline was used as the placebo. The incidence of headache and its severity at one, 4, 12, and 24 hours postoperatively, nausea and its severity were also measured and compared. Independent

resultsThe data revealed that low dose intravenous ketamine significantly decreased patients' headaches (P = 0.001), the sensation of pruritus (P = 0.009), and the need for analgesic (P = 0.001). Furthermore, the sensation of postoperative nausea was less in the case group. The patients in the case and control groups had no significant difference in terms of hypertension or bradycardia (P = 0.717 and 0.939, respectively).

conclusionsThe injection of ketamine as a premedication in the cesarean section can reduce the severity of postoperative headache in mothers. Therefore, it is recommended to use ketamine as an anti-headache drug in pregnant women.

Indexed as

Cesarean SectionHeadacheKetamineSpinal Anesthesia

Identifiers

PMID32280620
PMCPMC7118677
OpenAlexW2991120681

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.