ArticleJournal of global health2020
Evaluating coverage of maternal syphilis screening and treatment within antenatal care to guide service improvements for prevention of congenital syphilis in
Article in Journal of global health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Implementation and Innovation in Syphilis Diagnostics: Insights from Global Health Systems, Molecular Testing, and Self-Testing Strategies.Sexually transmitted diseases · 2026Article
- Resilience paths: maternal experiences in coping with syphilis exposure or congenital infection and the role of support networks.BMC pregnancy and childbirth · 2026Article
- "As long as you are married you cannot protect yourself against syphilis": qualitative exploration of syphilis risk perception and antenatal care seeking among pregnant women in Uganda.BMC public health · 2026Article
- Assessing progress towards the elimination of mother-to-child transmission of syphilis in Peru: A national retrospective analysis.PLOS global public health · 2026Article
- A case report of congenital pemphigus syphiliticus in a preterm neonate: Insights into diagnosis, treatment, and long-term follow-up in a resource-limited country (Cambodia).SAGE open medical case reports · 2025Article
- Cost-effectiveness of integrated maternal HIV, syphilis, and hepatitis B screening opt-out strategies in Nepal: a modelling study.The Lancet regional health. Southeast Asia · 2025Article
- Factors influencing the implementation of integrated screening for HIV, syphilis, and hepatitis B for pregnant women in Nepal: A qualitative study.PLOS global public health · 2024Article
- Estimating the real burden of gestational syphilis in Brazil, 2007-2018: a Bayesian modeling study.Lancet regional health. Americas · 2023Article
- Congenital Syphilis: a Review of Global Epidemiology.Clinical microbiology reviews · 2023Review
- Towards the elimination of mother to child transmission of syphilis 2015-2020: practice and progress in Zhejiang province, eastern China.BMC pregnancy and childbirth · 2023Article
- Article
- Evaluating the effect of the plan of national syphilis control in controlling the syphilis epidemic in Jiangsu, China 2010-2020.Frontiers in public health · 2023Article
- Adverse pregnancy outcomes and associated risk factors among pregnant women with syphilis during 2013-2018 in Hunan, China.Frontiers in medicine · 2023Article
- Underreporting of unfavorable outcomes of congenital syphilis on the Notifiable Health Conditions Information System in the state of São Paulo, Brazil, 2007-2018.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2023Article
- Point-of-Care Diagnostics for Diagnosis of Active Syphilis Infection: Needs, Challenges and the Way Forward.International journal of environmental research and public health · 2022Article
- Article
- The importance of improving intervention coverage measurement for ensuring all women, children and adolescents are reached with the health care services they need.Journal of global health · 2020Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCountdown to 2030 (CD2030) tracks progress in the 81 countries that account for more than 90% of under-five child deaths and 95% of maternal deaths in the world. In 2017, CD2030 identified syphilis screening and treatment during antenatal care (ANC) as priority indicators for monitoring.
methodsCountry-reported data in the UNAIDS Global AIDS Monitoring System (GAM) system were used to evaluate four key syphilis indicators from CD2030 countries: (1) maternal syphilis screening and (2) treatment coverage during ANC, (3) syphilis seroprevalence among ANC attendees, and (4) national congenital syphilis (CS) case rates. A cascade analysis for CD2030 countries with coverage data for the number of women attending at least 4 antenatal care visits (ANC4), syphilis testing, seroprevalence and treatment was performed to estimate the number of CS cases that were attributable to missed opportunities for syphilis screening and treatment during antenatal care.
resultsOf 81 countries, 52 (64%) reported one or more values for CS indicators into the GAM system during 2016-2017; only 53 (65%) had maternal syphilis testing coverage, 41 (51%) had screening positivity, and 40 (49%) had treatment coverage. CS case rates were reported by 13 (16%) countries. During 2016-2017, four countries reported syphilis screening and treatment coverage of ≥95% consistent with World Health Organization (WHO) targets. Sufficient data were available for 40 (49%) of countries to construct a cascade for data years 2016 and 2017. Syphilis screening and treatment service gaps within ANC4 resulted in an estimated total of 103 648 adverse birth outcomes with 41 858 of these occurring as stillbirths among women attending ANC4 (n = 31 914 408). Women not in ANC4 (n = 25 619 784) contributed an additional 67 348 estimated adverse birth outcomes with 27 198 of these occurring as stillbirths for a total of 69 056 preventable stillbirths attributable to syphilis in these 40 countries.
conclusionThese data and findings can serve as an initial baseline evaluation of antenatal syphilis surveillance and service coverage and can be used to guide improvement of delivery and monitoring of syphilis screening and treatment in ANC for these priority countries.
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