Evidence map›Paper›PMID 32280282›Full record

ArticleInternational journal of women's health2020

Bleeding Pattern and Management of Unexpected Bleeding/Spotting with an Extended Regimen of a Combination of Ethinylestradiol 20 mcg and Drospirenone 3 mg.

Rogerio Bonassi Machado, Luciano de Melo Pompei, Rosires Andrade, Eliana Nahas, Cristina Guazzelli, Maria Celeste Wender, Achilles Machado Cruz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of women's health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 1 country.

Rogerio Bonassi MachadoDepartment of Gynecology and Obstetrics, Jundiaí School of Medicine, Jundiaí, São Paulo 13202-550, Brazil.ORCID 0000-0001-9361-0905
Luciano de Melo PompeiDepartment of Gynecology and Obstetrics, ABC School of Medicine, Santo André, São Paulo 09060-650, Brazil.ORCID 0000-0001-7084-037X
Rosires AndradeDepartment of Gynecology and Obstetrics, Federal University of Parana, Curitiba, Paraná 80060-240, Brazil.ORCID 0000-0001-8621-3020
Eliana NahasDepartment of Gynecology and Obstetrics, Botucatu Medical School (Unesp), Botucatu, São Paulo 18618970, Brazil.
Cristina GuazzelliDepartment of Obstetrics, Federal University of Sao Paulo, São Paulo 04024-002, Brazil.ORCID 0000-0002-6985-0818
Maria Celeste WenderDepartment of Gynecology and Obstetrics, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90035-903, Brazil.ORCID 0000-0001-9085-4605
Achilles Machado CruzDepartment of Clinical Research, Libbs Farmacêutica Ltda, São Paulo 01140-050, Brazil.
Faculdade de Medicina de Jundiaí · BRFaculdade de Medicina do ABC · BRLibbs (Brazil) · BRUniversidade Estadual Paulista (Unesp) · BRUniversidade Federal de São Paulo · BRUniversidade Federal do Paraná · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the bleeding pattern in women using ethinylestradiol 20 mcg/drospirenone 3 mg (EE 20 mcg/DRSP 3 mg) in a 24/4-day cyclic regimen with an extended regimen. Unexpected bleeding/spotting in the extended regimen group was managed by allowing a 4-day hormone-free interval (HFI).

methodsThis was a randomized, prospective, open-label, multicenter study. Participants (N = 348) were randomized to receive EE 20 mcg/DRSP 3 mg in either an extended regimen (EE/DRSP

resultsEE/DRSP

conclusionThe use of EE 20 mcg/DRSP 3 mg in an extended regimen resulted in high rates of amenorrhea and "no bleeding". Unexpected bleeding/spotting in the EE/DRSP CLINICAL

trial registrationInternational Standard Randomised Controlled Trial Number (ISRCTN57661673): http://www.controlled-trials.com/isrctn/pf/57661673.

Indexed as

bleeding profilecombined oral contraceptivesdrospirenoneextended regimenlow dose oral contraceptive

Identifiers

PMID32280282
PMCPMC7125311
OpenAlexW3013394614

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.