Evidence map›Paper›PMID 32280257›Full record

ArticleClinical, cosmetic and investigational dermatology2020

A Large Cross-Sectional Survey Study of the Prevalence of Alopecia Areata in the United States.

Michael Benigno, Kathryn P Anastassopoulos, Arash Mostaghimi, Margarita Udall, Shoshana R Daniel, Joseph C Cappelleri, Pratibha Chander, Peter M Wahl, Jennifer Lapthorn, Laura Kauffman and 2 more

Open access · goldAbstract read
In one paragraph

Article in Clinical, cosmetic and investigational dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Psychosocial and mental impact of alopecia areata: Analysis of the Danish Skin Cohort.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Michael BenignoPfizer Inc, New York, NY 10017, USA.ORCID 0000-0002-6416-2696
Kathryn P AnastassopoulosCovance Market Access Services Inc, Gaithersburg, MD 20878, USA.ORCID 0000-0002-2868-2467
Arash MostaghimiBrigham & Women's Hospital, Harvard University, Boston, MA 02115, USA.
Margarita UdallPfizer Inc, New York, NY 10017, USA.ORCID 0000-0001-9019-3747
Shoshana R DanielPfizer Inc, New York, NY 10017, USA.ORCID 0000-0003-4601-0338
Joseph C CappelleriPfizer Inc., Groton, CT 06340, USA.ORCID 0000-0001-9586-0748
Pratibha ChanderPfizer Inc, New York, NY 10017, USA.
Peter M WahlCovance Market Access Services Inc, Gaithersburg, MD 20878, USA.
Jennifer LapthornCovance Market Access Services Inc, Gaithersburg, MD 20878, USA.
Laura KauffmanCovance Market Access Services Inc, Gaithersburg, MD 20878, USA.
Linda ChenPfizer Inc, New York, NY 10017, USA.ORCID 0000-0001-7078-163X
Elena PeevaPfizer Inc., Cambridge, MA 02139, USA.
Pfizer (United States) · USCovance (United States) · USBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlopecia areata (AA) is an autoimmune disease characterized by the development of non-scarring alopecia. The prevalence is not well known, and estimates vary considerably with no recent estimates in the United States (US). The objective of this study was to define the current AA point prevalence estimate among the general population in the US overall and by severity. PATIENTS AND

methodsWe administered an online, cross-sectional survey to a representative sample of the US population. Participants self-screening as positive for AA using the Alopecia Assessment Tool (ALTO) also completed the Severity of Alopecia Tool (SALT) to measure the severity of disease as a percent of scalp hair loss. Self-reported AA participants were invited to upload photographs for adjudication of AA by 3 clinicians.

resultsThe average age of participants was 43 years. Approximately half of the participants (49.2%) were male, and the majority were white (77.1%) and not of Hispanic origin (93.2%). Among the 511 self-reported AA participants, 104 (20.4%) uploaded photographs for clinician evaluation. Clinician-adjudicated point prevalence of AA was 0.21% (95% CI: 0.17%, 0.25%) overall, 0.12% (95% CI: 0.09%, 0.15%) for "mild" disease (≤50% SALT score), and 0.09% (95% CI: 0.06%, 0.11%) for "moderate to severe" disease (>50% SALT score) with 0.04% (95% CI: 0.02%, 0.06%) for the alopecia totalis/alopecia universalis (100% SALT score) "moderate to severe" subgroup. The average SALT score was 44.4% overall, 8.8% for "mild", and 93.4% for "moderate to severe".

conclusionThis study suggests that the current AA prevalence in the US is similar to the upper estimates from the 1970s at approximately 0.21% (700,000 persons) with the current prevalence of "moderate to severe" disease at approximately 0.09% (300,000 persons). Given this prevalence and the substantial impact of AA on quality of life, the burden of AA within the US is considerable.

Indexed as

Alopecia Assessment ToolepidemiologySeverity of Alopecia Toolteledermatology

Identifiers

PMID32280257
PMCPMC7131990
OpenAlexW3014138588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.