ArticleNeuropsychiatric disease and treatment2020
Factors Associated with Non-Remission in Bipolar Disorder: The Multicenter Treatment Survey for Bipolar Disorder in Psychiatric Outpatient Clinics (MUSUBI).
Article in Neuropsychiatric disease and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Associations Between Depressive Symptoms, Cognitive Impairment, and Work Productivity Loss in Patients With Bipolar Disorder: A 48-Week Longitudinal Analysis.Neuropsychopharmacology reports · 2025Article
- Investigating the frequency of tick-borne infections in a case series of 37 youth diagnosed with pediatric bipolar disorder.Frontiers in child and adolescent psychiatry · 2025Article
- Real-world clinical determinants of alcohol dependence in outpatients with bipolar disorder: a multicenter treatment survey for bipolar disorder in psychiatric outpatient clinics with 2,392 participants.Frontiers in psychiatry · 2024Article
- Real-world predictors of divorce among outpatients with bipolar disorder: sex differences and clinical implications.Annals of general psychiatry · 2023Article
- Costs of psychotropics for outpatients with bipolar disorder in Japan; the MUSUBI 2016 survey.Annals of medicine · 2023Article
- Assessments of functional outcomes and its determinants among bipolar disorder patients in Northwest Ethiopia comprehensive specialized hospitals: a multicenter hospital-based study.Annals of general psychiatry · 2023Article
- Clinical characteristics and prescriptions associated with a 2-year course of rapid cycling and euthymia in bipolar disorder: a multicenter treatment survey for bipolar disorder in psychiatric clinics.Frontiers in psychiatry · 2023Article
- Predictors of psychiatric hospitalization among outpatients with bipolar disorder in the real-world clinical setting.Frontiers in psychiatry · 2023Article
- Proportion of subjects with psychotic features in bipolar disorder correlated with treatment response by antipsychotics for acute mania.Psychiatry and clinical neurosciences · 2022Article
- Effect of age and sex on prescriptions for outpatients with bipolar disorder in the MUSUBI study: a cross‑sectional study.Annals of general psychiatry · 2022Article
- Relationship Between Employment Status and Unstable Periods in Outpatients with Bipolar Disorder: A Multicenter Treatment Survey for Bipolar Disorder in Psychiatric Outpatient Clinics (MUSUBI) Study.Neuropsychiatric disease and treatment · 2022Article
- Bipolar Disorder and Polysubstance Use Disorder: Sociodemographic and Clinical Correlates.Frontiers in psychiatry · 2022Article
- Real-world clinical predictors of manic/hypomanic episodes among outpatients with bipolar disorder.PloS one · 2021Observational
- Relationship Between Mood Episode and Employment Status of Outpatients with Bipolar Disorder: Retrospective Cohort Study from the Multicenter Treatment Survey for Bipolar Disorder in Psychiatric Clinics (MUSUBI) Project.Neuropsychiatric disease and treatment · 2021Article
- Real-World Treatment Patterns and Adherence to Oral Medication Among Patients with Bipolar Disorders: A Retrospective, Observational Study Using a Healthcare Claims Database.Neuropsychiatric disease and treatment · 2021Article
- Factors Associated with Doses of Mood Stabilizers in Real-world Outpatients with Bipolar Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- Real-world clinical features of and antidepressant prescribing patterns for outpatients with bipolar disorder.BMC psychiatry · 2020Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to identify factors associated with non-remission in bipolar disorder. PATIENTS AND
methodsThe multicenter treatment survey for bipolar disorder in psychiatric outpatient clinics (MUSUBI) study used a questionnaire administered at 176 clinics throughout Japan from September to October 2016. Clinic psychiatrists performed a retrospective medical record survey of consecutive cases with bipolar disorder. Patients were considered to be in remission if they met all of the following criteria: they were not in a mixed state, their manic or depressive symptoms were either borderline or nonexistent (corresponding to 2 or 1 points on the Clinical Global Impressions Scale, Bipolar Version), and their psychiatrists clinically considered them to be in remission. Enrolled patients were classified into remitters group and non-remitters group and demographic and clinical characteristics were contrasted between the groups. Non-remitters were compared with remitters, using a series of logistic regression analyses.
resultsA total of 3130 patients (1420 men; mean age: 50.3 years) were included in this study; 1307 patients (41.8%) were in remission. Of the remaining 1823 patients, 1260 (40.3%) had mild to severe depression, 261 (8.3%) suffered from manic or hypomanic episodes, and 302 (9.6%) were in a mixed state. Logistic regression analyses found the following eight factors to be significantly correlated with non-remission in patients with bipolar disorder: female gender, younger age, unemployed status, rapid cycling pattern, comorbid alcohol/substance abuse, poorer social function, lithium non-use, and antidepressant use.
conclusionThe MUSUBI study, the largest nationwide investigation on bipolar disorder, identified eight clinically relevant factors associated with non-remission in bipolar patients. They have important clinical implications; further prospective studies are necessary to replicate these findings and to guide better managements for those in serious needs.
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