ArticleJournal of the mechanical behavior of biomedical materials2020
Structure, mechanical properties, and modeling of cyclically compressed pulmonary emboli.
Article in Journal of the mechanical behavior of biomedical materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Advancing Pulmonary Embolism Detection with Integrated Deep Learning Architectures.Journal of imaging informatics in medicine · 2026Article
- Cellular and enzymatic features of thrombi in humans are vascular bed dependent.Blood vessels, thrombosis & hemostasis · 2025Article
- Flow affects the structural and mechanical properties of the fibrin network in plasma clots.Journal of materials science. Materials in medicine · 2024Article
- A Fluid-Structure Interaction Analysis of Blood Clot Motion in a Branch of Pulmonary Arteries.Cardiovascular engineering and technology · 2023Article
- Biomechanical origins of inherent tension in fibrin networks.Journal of the mechanical behavior of biomedical materials · 2022Article
- Humidity dependence of fracture toughness of cellulose fibrous networks.Engineering fracture mechanics · 2022Article
- Thrombus Structural Composition in Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- Visualizing thrombosis to improve thrombus resolution.Research and practice in thrombosis and haemostasis · 2021Article
- Fibrous gels modelled as fluid-filled continua with double-well energy landscape.Proceedings. Mathematical, physical, and engineering sciences · 2020Article
- Association Between Inferior Vena Cava-Involved Thrombosis, Severe Iliac Vein Stenosis, and Proximal Pulmonary Embolism in Patients With Deep Vein Thrombosis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Pulmonary embolism occurs when blood flow to a part of the lungs is blocked by a venous thrombus that has traveled from the lower limbs. Little is known about the mechanical behavior of emboli under compressive forces from the surrounding musculature and blood pressure. We measured the stress-strain responses of human pulmonary emboli under cyclic compression, and showed that emboli exhibit a hysteretic stress-strain curve. The fibrin fibers and red blood cells (RBCs) are damaged during the compression process, causing irreversible changes in the structure of the emboli. We showed using electron and confocal microscopy that bundling of fibrin fibers occurs due to compression, and damage is accumulated as more cycles are applied. The stress-strain curves depend on embolus structure, such that variations in composition give quantitatively different responses. Emboli with a high fibrin component demonstrate higher normal stress compared to emboli that have a high RBC component. We compared the compression response of emboli to that of whole blood clots containing various volume fractions of RBCs, and found that RBCs rupture at a certain critical stress. We describe the hysteretic response characteristic of foams, using a model of phase transitions in which the compressed foam is segregated into coexisting rarefied and densified phases whose fractions change during compression. Our model takes account of the rupture of RBCs in the compressed emboli and stresses due to fluid flow through their small pores. Our results can help in classifying emboli as rich in fibrin or rich in red blood cells, and can help in understanding what responses to expect when stresses are applied to thrombi in vivo.
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