Evidence map›Paper›PMID 32279528›Full record

Observational studyAIDS care2021

The association between severe menopausal symptoms and engagement with HIV care and treatment in women living with HIV.

Danielle Solomon, Caroline A Sabin, Fiona Burns, Richard Gilson, Sris Allan, Annamiek de Ruiter, Rageshri Dhairyawan, Julie Fox, Yvonne Gilleece, Rachael Jones and 6 more

Abstract readObservational Study
In one paragraph

Observational study in AIDS care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Impact of Vaginal Estradiol on the Genitourinary Syndrome of Menopause, Vaginal Microbiome and Mucosal Immune Mediators in Women With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Trial
  3. HIV update for the non-HIV specialist and general physician.Clinical medicine (London, England) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Danielle SolomonInstitute for Global Health, University College London, UK.
Caroline A SabinInstitute for Global Health, University College London, UK.
Fiona BurnsInstitute for Global Health, University College London, UK.
Richard GilsonInstitute for Global Health, University College London, UK.
Sris AllanCoventry and Warwickshire Partnership NHS Trust, UK.
Annamiek de RuiterGuy's & St Thomas' NHS Foundation Trust, UK.
Rageshri DhairyawanBarking, Havering and Redbridge NHS Trust, UK.
Julie FoxGuy's & St Thomas' NHS Foundation Trust, UK.
Yvonne GilleeceBrighton & Sussex University Hospitals NHS Trust, UK.
Rachael JonesChelsea and Westminster Hospital NHS Foundation Trust, UK.
Frank PostKing's College Hospital NHS Foundation Trust, UK.
Iain ReevesHomerton University Hospital NHS Foundation Trust, UK.
Jonathan RossUniversity Hospital Birmingham NHS Foundation Trust, UK.
Andrew UstianowskiNorth Manchester General Hospital, Penine Acute Hospitals NHS Trust, UK.
Jane ShepherdUK Community Advisory Board.
S TariqInstitute for Global Health, University College London, UK.ORCID 0000-0001-9802-7727

Funding

Department of Health PDF-2014-07-071Wellcome TrustWellcome Trust 102186/B/13/ZWellcome Trust 204841/Z/16/Z
6 · The paper itself

Abstract

Using data from the PRIME Study, an observational study of the menopause in women living with HIV in England, we explored the association between menopausal symptoms and: (i) antiretroviral therapy (ART) adherence and (ii) HIV clinic attendance. We measured menopausal symptom severity with the Menopause Rating Scale (MRS, score ≥17 indicating severe symptoms), adherence with the CPCRA Antiretroviral Medication Adherence Self-Report Form, and ascertained HIV clinic attendance via self-report. Odds ratios were obtained using logistic regression. Women who reported severe menopausal symptoms had greater odds of suboptimal ART adherence (adjusted odds ratio (AOR) 2.22; 95% CI 1.13, 4.35) and suboptimal clinic attendance (AOR 1.52; 95% CI 1.01, 2.29). When psychological, somatic and urogenital domains of the MRS were analysed individually there was no association between adherence and severe symptoms (all

Indexed as

Drug MonitoringAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveEnglandFemaleHIV InfectionsHot FlashesHumansMenopauseMiddle AgedAnti-Retroviral Agentsadherenceageingclinic attendancehivMenopausewomen

Identifiers

PMID32279528
PMCPMC8043570

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.