Evidence map›Paper›PMID 32279445›Full record

ArticleChemical biology & drug design2020

Synthesis, pharmacological evaluations, and molecular docking studies on a new 1,3,4,11b-tetrahydro-1H-fluoreno[9,1-cd]azepine framework: Rigidification of D

Rajan Giri, Ian Alberts, Wayne W Harding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical biology & drug design, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rajan GiriDepartment of Chemistry, Hunter College, City University of New York, NY, USA.
Ian AlbertsDepartment of Natural Sciences, LaGuardia Community College, Long Island City, NY, USA.
Wayne W HardingDepartment of Chemistry, Hunter College, City University of New York, NY, USA.ORCID 0000-0002-1866-3553

Funding

Novel anti-cocaine D1 partial agonistsSC1DA049961 · NIDA · HUNTER COLLEGE · PI HARDING, WAYNE WESLEY · 2019 to 2022
$1.6M
NIDA NIH HHS SC1 DA049961
6 · The paper itself

Abstract

The novel 1,3,4,11b-tetrahydro-1H-fluoreno[9,1-cd]azepine framework, a structurally rigidified variant of the 1-phenylbenzazepine template, was synthesized via direct arylation as a key reaction. Evaluation of the binding affinities of the rigidified compounds across a battery of serotonin, dopamine, and adrenergic receptors indicates that this scaffold unexpectedly has minimal affinity for D

Indexed as

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAzepinesBenzazepinesDopamine AgonistsHydrogen BondingLigandsMolecular ConformationMolecular Docking SimulationProtein BindingReceptors, Dopamine D1Receptors, SerotoninStructure-Activity Relationship1-phenylbenzazepine2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAzepinesBenzazepinesDopamine AgonistsLigandsReceptors, Dopamine D1Receptors, Serotoninserotonin 6 receptorSK&F 756705-HT6benzazepineD1dockingdopamine receptorserotonin receptor

Identifiers

PMID32279445
PMCPMC7442682

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.