Evidence map›Paper›PMID 32279416›Full record

ArticleLiver international : official journal of the International Association for the Study of the Liver2020

Preoperative evaluation of microvascular invasion with circulating tumour DNA in operable hepatocellular carcinoma.

Dong Wang, Yaping Xu, Jennifer B Goldstein, Ke Ye, Xi Hu, Liang Xiao, Lifeng Li, Lianpeng Chang, Yanfang Guan, Guo Long and 6 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver international : official journal of the International Association for the Study of the Liver, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05371873 (A Prospective Study of Early Warning and Predictive Indicators Related to the Individualized Staging and Prognosis in Liver Cancer Patients), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05371873 unknown statusnot on this mapstarted 2021, after this paper: background citation

A Prospective Study of Early Warning and Predictive Indicators Related to the Individualized Staging and Prognosis in Liver Cancer Patients

TypeobservationalSponsorFirst Affiliated Hospital of Zhejiang UniversityRan2021 to 2025Enrolled250ConditionsHepatocellular CarcinomaArmsLiver resection method
3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
  10. [Research progress of microvascular invasion in hepatocellular carcinoma].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Preoperative evaluation of microvascular invasion with circulating tumour DNA in operable hepatocellular carcinoma.Liver international : official journal of the International Association for the Study of the Liver · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Dong WangDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yaping XuGeneplus-Beijing Institute, Beijing, China.ORCID 0000-0002-6741-3913
Jennifer B GoldsteinDivision of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ke YeDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xi HuDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Liang XiaoDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lifeng LiGeneplus-Beijing Institute, Beijing, China.
Lianpeng ChangGeneplus-Beijing Institute, Beijing, China.
Yanfang GuanGeneplus-Beijing Institute, Beijing, China.
Guo LongDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qiongzhi HeGeneplus-Beijing Institute, Beijing, China.
Xin YiGeneplus-Beijing Institute, Beijing, China.
Jianjun ZhangDepartment of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zhiming WangDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xuefeng XiaGeneplus-Beijing Institute, Beijing, China.
Ledu ZhouDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0000-0003-0702-0429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsMicrovascular invasion (MVI) is a critical prognostic factor for operable hepatocellular carcinoma (HCC). This study aimed to explore the performance of circulating tumour DNA (ctDNA) in evaluating MVI status preoperatively.

methodsSeventy-three HCC patients were enrolled and randomly divided into a training cohort and a validation cohort in a 2:1 ratio, and preoperative blood and surgical tissue samples were obtained. Genomic alterations were analysed using targeted deep sequencing with a 1021-gene panel.

resultsIn training cohort, 260 somatic mutations were identified in 40 blood samples (81.6%). CtDNA mutation was verified in paired tissue sample in 39 patients (97.5%). In univariate analysis, ctDNA allele frequency (AF) and largest tumour diameter were associated with the presence of MVI, but ctDNA AF was the only independent risk factor in multivariate analysis. With the cut-off value of 0.83%, ctDNA AF determined the presence of MVI with the sensitivity of 89.7% and specificity of 80.0% in the training cohort, and the sensitivity of 78.6% and the specificity of 81.8% in the validation cohort. In preoperative evaluation, ctDNA AF, AFP level and BCLC staging were associated with recurrence-free survival in both univariate and multivariate analysis.

conclusionsCtDNA can serve as an independent risk factor of MVI for operable HCC and help determining precise treatment strategies. The integration of ctDNA in the management of operable HCC may achieve better clinical outcomes.

Indexed as

Carcinoma, HepatocellularCirculating Tumor DNALiver NeoplasmsHepatectomyHumansMicrovesselsNeoplasm InvasivenessRetrospective StudiesCirculating Tumor DNActDNAhepatectomyhepatocellular carcinomamicrovascular invasionsurgical management

Identifiers

PMID32279416
PMCPMC7496978

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.