Evidence map›Paper›PMID 32279237›Full record

ArticleIrish journal of medical science2020

The levels of advanced oxidation protein products in patients with obstructive sleep apnea syndrome.

Ali Rıza Yağmur, Mehmet Ali Çetin, Süleyman Emre Karakurt, Turan Turhan, Hacı Hüseyin Dere

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Article in Irish journal of medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Melatonin and oxidative DNA damage in REM- and NREM-related obstructive sleep apnea: an exploratory analysis of sleep-stage phenotypes.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
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  7. Review
  8. Oxidative Stress Markers among Obstructive Sleep Apnea Patients.Oxidative medicine and cellular longevity · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ali Rıza YağmurDepartment of Otorhinolaryngology, Head and Neck Surgery, Ankara City Hospital, Ankara, Turkey. aryamur19@gmail.com.ORCID https://orcid.org/0000-0001-6283-2505
Mehmet Ali ÇetinDepartment of Otorhinolaryngology, Head and Neck Surgery, Ankara City Hospital, Ankara, Turkey.ORCID https://orcid.org/0000-0003-0479-7304
Süleyman Emre KarakurtDepartment of Otorhinolaryngology, Head and Neck Surgery, Ankara City Hospital, Ankara, Turkey.ORCID https://orcid.org/0000-0002-3394-8119
Turan TurhanDepartment of Biochemistry, Ankara City Hospital, Ankara, Turkey.ORCID https://orcid.org/0000-0002-7316-1273
Hacı Hüseyin DereDepartment of Otorhinolaryngology, Head and Neck Surgery, Ankara City Hospital, Ankara, Turkey.ORCID https://orcid.org/0000-0003-0750-9590
Memorial Ankara Hospital · TRAnkara University · TR

Funding

Ankara Numune Egitim ve Arastirma Hastanesi 1205/2016
6 · The paper itself

Abstract

backgroundObstructive sleep apnea syndrome (OSAS) is characterized by repeated episodes of complete or partial obstructions of the upper airway during sleep, frequently followed by transient hypoxemia. Advanced oxidation protein products (AOPP) are a family of oxidized protein products, and oxidative stress has a substantial role in the morbidity of OSAS.

aimsThe aim of this study was to investigate the serum levels of advanced oxidation protein products (AOPP) as a marker of oxidative stress, and their correlation with polysomnographic parameters in patients with obstructive sleep apnea syndrome (OSAS). Additionally, we investigated the effect of positive airway pressure (PAP) treatment on serum AOPP values and compared the levels before and after the treatment.

methodsThe study enrolled a total of 125 subjects including 59 patients with severe OSAS, 34 patients with moderate OSAS, 32 patients with mild OSAS, and 40 healthy controls. Mean AOPP values were compared between OSAS groups and control groups. Correlations between AOPP and polysomnographic parameters were investigated. Mean AOPP values before and after 6-month PAP therapy were compared.

resultsSignificantly elevated AOPP levels were found in severe and moderate OSAS groups in comparison with mild OSAS and control groups. AOPP was directly correlated with apnea-hypopnea index, percentage of total time spent with oxygen saturation below 90%, oxygen desaturation index, maximum obstructive apnea duration, arousal index, and number of obstructive apneas accompanying bradycardia but inversely correlated with average SPO

conclusionsAOPP, which is an oxidative stress marker, was found to be high in OSAS patients. Especially, high levels in moderate and severe OSAS patients may be an indicator of increased morbidity. After 6 months of PAP treatment, there was no statistically significant change in these levels.

Indexed as

AdultAdvanced Oxidation Protein ProductsFemaleHumansMaleOxidative StressPolysomnographySleep Apnea, ObstructiveYoung AdultAdvanced Oxidation Protein ProductsAdvanced oxidation protein productsObstructive sleep apnea syndromeOxidative stressPolysomnography

Identifiers

PMID32279237
OpenAlexW3015248126

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.