Evidence map›Paper›PMID 32279229›Full record

ArticleOdontology2021

Effect of curcumin on growth, biofilm formation and virulence factor gene expression of Porphyromonas gingivalis.

Vijay M Kumbar, Malleswara Rao Peram, Manohar S Kugaji, Tejas Shah, Sanjivani P Patil, Uday M Muddapur, Kishore G Bhat

Abstract read
PubMed Publisher
In one paragraph

Article in Odontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 104 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Differential Gene Expression ofInternational journal of molecular sciences · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Effects of Curcumin on Biofilm Production and Associated Gene in Multidrug-ResistantInternational journal of molecular and cellular medicine · 2025
    Article
  12. Review
  13. Review
  14. Article
  15. Antibacterial activity ofFuture microbiology · 2024
    Article
  16. Curcumin inhibits growth ofJournal of oral microbiology · 2024
    Article
  17. Article
  18. Benefits of Natural Antioxidants on Oral Health.Antioxidants (Basel, Switzerland) · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Vijay M KumbarCentral Research Laboratory, Maratha Mandal's Nathajirao G. Halgekar Institute of Dental Sciences and Research Centre, Near KSRP Ground, Bauxite road, Belgaum, Karnataka, 590 010, India.ORCID http://orcid.org/0000-0001-6261-1665
Malleswara Rao PeramCentral Research Laboratory, Maratha Mandal's Nathajirao G. Halgekar Institute of Dental Sciences and Research Centre, Near KSRP Ground, Bauxite road, Belgaum, Karnataka, 590 010, India.ORCID http://orcid.org/0000-0002-1984-6538
Manohar S KugajiCentral Research Laboratory, Maratha Mandal's Nathajirao G. Halgekar Institute of Dental Sciences and Research Centre, Near KSRP Ground, Bauxite road, Belgaum, Karnataka, 590 010, India.ORCID http://orcid.org/0000-0001-6315-4531
Tejas ShahDepartment of Biotechnology, Sinhgad College of Engineering, Affiliated to Savitribai Phule Pune University, Vadgaon Budruk, Sinhagad Road, Pune, Maharashtra, 411 0 41, India.
Sanjivani P PatilCentral Research Laboratory, Maratha Mandal's Nathajirao G. Halgekar Institute of Dental Sciences and Research Centre, Near KSRP Ground, Bauxite road, Belgaum, Karnataka, 590 010, India.
Uday M MuddapurDepartment of Biotechnology, KLE Technological University (Formerly Known as B.V.Bhoomaraddi College of Engineering and Technology), BVB Campus, Hubli, Karnataka, 580031, India.
Kishore G BhatCentral Research Laboratory, Maratha Mandal's Nathajirao G. Halgekar Institute of Dental Sciences and Research Centre, Near KSRP Ground, Bauxite road, Belgaum, Karnataka, 590 010, India. drkgbhat@yahoo.com.ORCID http://orcid.org/0000-0002-9563-2531
National Institute of Technology Karnataka · INKLE Technological University · INSavitribai Phule Pune University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porphyromonas gingivalis is a keystone pathogen and major colonizer in host tissue which plays a pivotal role in periodontitis among the other polymicrobial infections. Increasing facts demonstrate that curcumin has antibacterial activity and anti-biofilm effect against the periodontopathogens through diverse mechanisms that have a positive impact on periodontal health. The present study was aimed to elucidate the effect of curcumin on biofilm formation and virulence factor gene expression of P. gingivalis. By using gene expression studies, we exploited the mechanism of anti-biofilm effects of curcumin on P. gingivalis. The minimum inhibitory concentration and minimum bactericidal concentration of curcumin for both ATCC and clinical strains of P. gingivalis were found to be 62.5 and 125 µg ml

Indexed as

CurcuminPorphyromonas gingivalisAdhesins, BacterialBiofilmsGene ExpressionVirulence FactorsAdhesins, BacterialCurcuminVirulence FactorsAntibacterialBiofilmCurcuminPorphyromonas gingivalisRT-PCRVirulence factors

Identifiers

PMID32279229
OpenAlexW3015261963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.