ReviewDigestive diseases and sciences2020
Strictures in Crohn's Disease: From Pathophysiology to Treatment.
Review in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Collagen-binding probe PET/MR for distinguishing fibrotic from inflammatory strictures in Crohn's disease.European journal of nuclear medicine and molecular imaging · 2026Observational
- Analysis of Periostin, TGF-β, and SLUG Expression in Inflammatory Bowel Disease in Pediatric Patients and Their Clinical Implications.Journal of clinical medicine · 2026Article
- Surgery-induced and Associated Long-term Strictures.Clinics in colon and rectal surgery · 2026Review
- Article
- 3D Imaging of Crohn's Disease Strictures: A Novel Tool to Enhance Patient Understanding and Support Multidisciplinary Decision-Making.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Cost-Effectiveness of Endoscopic Stricturotomy Versus Resection Surgery for Crohn's Disease Strictures.Healthcare (Basel, Switzerland) · 2025Article
- Elastographic Histogram Analysis as a Non-Invasive Tool for Detecting Early Intestinal Remodeling in Experimental IBD.Journal of clinical medicine · 2025Article
- Effects of embryonic origin, tissue cues and pathological signals on fibroblast diversity in humans.Nature cell biology · 2025Review
- Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Article
- Surgical management of duodenal Crohn's disease.World journal of gastrointestinal surgery · 2023Article
- Review
- Transmural remission improves clinical outcomes up to 5 years in Crohn's disease.United European gastroenterology journal · 2023Article
- Ustekinumab is effective against ulcerative colitis with intestinal stenosis: A case report.Medicine · 2022Article
- Inflammation and tissue remodeling contribute to fibrogenesis in stricturing Crohn's disease: image processing and analysis study.Journal of pathology and translational medicine · 2022Article
- Medical, Endoscopic and Surgical Management of Stricturing Crohn's Disease: Current Clinical Practice.Journal of clinical medicine · 2022Review
- Current and Emerging Approaches to the Diagnosis and Treatment of Crohn's Disease Strictures.Gastroenterology & hepatology · 2022Article
- The Molecular Mechanisms of Intestinal Inflammation and Fibrosis in Crohn's Disease.Frontiers in physiology · 2022Review
- A systems biology analysis of protein-protein interaction of digestive disorders and Covid-19 virus based on comprehensive gene information.Gastroenterology and hepatology from bed to bench · 2022Article
- Co-expression of fibrotic genes in inflammatory bowel disease; A localized event?Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite recent advances aimed to treat transmural inflammation in Crohn's disease (CD) patients, the progression to a structuring behavior still represents an issue for clinicians. As inflammation becomes chronic and severe, the attempt to repair damaged tissue can result in an excessive production of extracellular matrix components and deposition of connective tissue, thus favoring the formation of strictures. No specific and accurate clinical predictors or diagnostic tools for intestinal fibrosis exist, and to date, no genetic or serological marker is in routine clinical use. Therefore, intestinal fibrosis is usually diagnosed when it becomes clinically evident and strictures have already occurred. Anti-fibrotic agents such as tranilast, peroxisome proliferator-activated receptor gamma agonists, rho kinase inhibitors, and especially mesenchymal stem cell therapy have provided interesting results, but most of the evidence has been derived from studies performed in vitro. Therefore, current therapy of fibrotic strictures relies mainly on endoscopic and surgical procedures. Although its long-term outcomes may be debated, endoscopic balloon dilation appears to be the safest and most effective approach to treat appropriately selected strictures. The use of endoscopic stricturotomy is currently limited by the expertise needed to perform it and by the few data available in the literature. Some good results have been achieved by the positioning of self-expandable metal stents (SEMS). However, there is no concordance regarding the type of stent to use and for how long it should be left in place. The development of new specific SEMS may lead to better outcomes and to an increased use of this alternative in CD-related strictures.
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