ArticleEuropean archives of psychiatry and clinical neuroscience2021
Functional near-infrared spectroscopy (fNIRS) as a tool to assist the diagnosis of major psychiatric disorders in a Chinese population.
Article in European archives of psychiatry and clinical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 58 citations in OpenAlex.
- The Immediate and sustained benefits of two-week high-frequency aerobic exercise on depressive symptoms and frontal function in subthreshold depression: A randomized controlled trial.Translational psychiatry · 2026Trial
- Examining dynamic changes in prefrontal connectivity and internalizing symptoms during the first and third trimesters of pregnancy.Journal of neuroendocrinology · 2026Article
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
- An interpretable TimeMIL framework for fNIRS: differential diagnosis between schizophrenia and bipolar disorder.Frontiers in psychiatry · 2026Article
- Frontotemporal cortical activity in Chinese male alcohol-dependent patients during a verbal fluency task: a functional near-infrared spectroscopy study.Frontiers in psychiatry · 2026Article
- Cross-Disease Classification of Depression, Bipolar Disorder, and Schizophrenia Using Multiscale Spatiotemporal Network Fusion Features From fNIRS.Depression and anxiety · 2026Article
- Differential cortical responses to neuromuscular electrical vs. peripheral magnetic stimulation: a multimodal TMS-fNIRS study.Frontiers in neuroscience · 2026Article
- Differences in brain functioning between obsessive-compulsive disorder and generalized anxiety disorder: a clinical study using functional near-infrared spectroscopy.Frontiers in psychiatry · 2026Article
- Article
- Differences in Prefrontal Cortex Activation Between Predominantly Positive and Negative Symptom Profiles in Schizophrenia: A Functional Near-Infrared Spectroscopy Study.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Serum lipid metabolic characteristics and potential biomarkers in first-episode schizophrenia.BMC psychiatry · 2025Article
- Functional Near-Infrared Spectroscopy in Schizophrenia Research: Progress, Challenges, and Future Directions.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Applications of Functional Near-Infrared Spectroscopy (fNIRS) in Monitoring Treatment Response in Psychiatry: A Scoping Review.Journal of clinical medicine · 2025Review
- Different prefrontal cortex activity patterns in bipolar and unipolar depression during verbal fluency tasks based on functional near infrared spectroscopy study.Scientific reports · 2025Article
- High-density multidistance fNIRS enhances detection of brain activity during a word-color Stroop task.Neurophotonics · 2025Article
- [Analysis of the relationship between acute stress disorder or posttraumatic stress disorder and total burn area in adult burn patients based on brain function detection results].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Article
- Mood symptoms, cognitive function, and changes of brain hemodynamics in patients with COVID-19: A functional near-infrared spectroscopy study.World journal of psychiatry · 2025Article
- Clinical value of predicting relapse within 3 months in alcohol-dependent patients using fNIRS in verbal fluency task.Scientific reports · 2025Article
- Prefrontal activation in bipolar and unipolar depression patients in the letter fluency tasks and category fluency tasks: a functional near-infrared spectroscopy study.Frontiers in psychiatry · 2025Article
- Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disorders.Frontiers in neurology · 2025Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
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Abstract
Advances in neuroimaging have promised the development of specific and objective biomarkers for the diagnosis and treatment of psychiatric disorders. Recently, functional near-infrared spectroscopy (fNIRS) has been used during cognitive tasks to measure cortical dysfunction associated with mental illnesses such as Schizophrenia (SCH), Major-Depressive disorder (MD) and Bipolar Disorder (BD). We investigated the ability of fNIRS as a clinically viable tool to successfully distinguish healthy individuals from those with major psychiatric disorders. 316 patients with major psychiatric disorders (198 SCH/54 MD/64 BP) and 101 healthy controls were included in this study. Changes in oxygenated-hemoglobin during a Chinese language verbal fluency test were measured using a 52-channel fNIRS machine over the bilateral temporal and frontal lobe areas. We evaluated the ability of two task-evoked features selected from prior studies the Integral and Centroid values, to identify individuals with major diagnoses. Both the integral value of frontal and centroid value of temporal showed sensitivity in classifying individuals with mental disorders from healthy controls. However, using a combined index featuring both the integral value and centroid value to differentiate psychiatric disorders from healthy controls with an AUC of 0.913, differentiate individuals with mood disorders from healthy controls showed an AUC of 0.899, while for schizophrenia the AUC was 0.737. Our data suggest that fNIRS can be used as a candidate biomarker during differential diagnosis individuals with mood or psychosis disorders and offer a step towards individualization of treatment.
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