Evidence map›Paper›PMID 32279129›Full record

ArticleNano convergence2020

Simple, rapid, and accurate malaria diagnostic platform using microfluidic-based immunoassay of Plasmodium falciparum lactate dehydrogenase.

Wang Sik Lee, Taejoon Kang, Kyung Jin Kwak, Kyoungsook Park, So Yeon Yi, Ui Jin Lee, Yong Beom Shin, Jinyoung Jeong

Open access · diamondAbstract read
In one paragraph

Article in Nano convergence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Wang Sik LeeEnvironmental Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
Taejoon KangBionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
Kyung Jin KwakEnvironmental Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
Kyoungsook ParkDept. of General Education, Daejeon Health Institute of Technology, 21 Chungjeon-ro, Dong-gu, Daejeon, 34504, Republic of Korea.
So Yeon YiBioNano Health Guard Research Center, 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
Ui Jin LeeBioNano Health Guard Research Center, 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
Yong Beom ShinDepartment of Nanobiotechnology, KRIBB School of Biotechnology, University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon, 34113, Republic of Korea.
Jinyoung JeongEnvironmental Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. jyjeong@kribb.re.kr.
Korea Research Institute of Bioscience and Biotechnology · KRChungnam National University · KRKorea University of Science and Technology · KRDaejeon Health Institute of Technology · KR

Funding

Ministry of Science and ICT (MSIT) NRF-2019R1C1C1006084Ministry of Science and ICT (MSIT) NRF-2019R1C1C1006867the Ministry of Science and ICT (MSIT) H-GUARD_2013M3A6B2078950
6 · The paper itself

Abstract

This work reports on a rapid diagnostic platform for the detection of Plasmodium falciparum lactate dehydrogenase (PfLDH), a representative malaria biomarker, using a microfluidic microplate-based immunoassay. In this study, the microfluidic microplate made it possible to diagnose PfLDH with a small volume of sample (only 5 μL) and short time (< 90 min) compared to conventional immunoassays such as enzyme-linked immunosorbent assay (ELISA). Moreover, the diagnostic performance of PfLDH showed high sensitivity, specificity, and selectivity (i.e., 0.025 pg/μL in phosphate-buffered saline and 1 pg/μL in human serum). The microfluidic-based microplate sensing platform has the potential to adapt simple, rapid, and accurate diagnoses to the practical detection of malaria.

Indexed as

DiagnosisImmunoassayMalariaMicrofluidic microplatePfLDH

Identifiers

PMID32279129
PMCPMC7150666
OpenAlexW3015633714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.