ArticleBrain stimulation
Neural selectivity, efficiency, and dose equivalence in deep brain stimulation through pulse width tuning and segmented electrodes.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of different types of deep brain stimulation on gait disorders in patients with Parkinson's disease: a network meta-analysis of randomized controlled trials.Frontiers in aging neuroscience · 2025Pooled it
- Efficacy of short pulse and conventional deep brain stimulation in Parkinson's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Pooled it
- Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data.Scientific reports · 2021Pooled it
- A Randomized, Double-Blinded Crossover Trial of Short Versus Conventional Pulse Width Subthalamic Deep Brain Stimulation in Parkinson's Disease.Journal of Parkinson's disease · 2022Trial
- Probabilistic comparison of gray and white matter coverage between depth and surface intracranial electrodes in epilepsy.Scientific reports · 2021Trial
- Home Health Management of Parkinson Disease Deep Brain Stimulation: A Randomized Clinical Trial.JAMA neurology · 2021Trial
- Metabolic activity in subcallosal cingulate predicts response to deep brain stimulation for depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Probabilistic mapping of tremor control and gait ataxia risk in deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Identification of low threshold off-target activation pathways during stimulation of carotid baroreceptor afferents in swine.bioRxiv : the preprint server for biology · 2026Article
- Fiber Distribution and Myelination of Dopaminergic Neurons in the Medial Forebrain Bundle of a Rodent Depression Model.Journal of neuroscience research · 2025Article
- Bradykinesia induced by pallidal neurostimulation in dystonia: clinical risk factors and anatomical mapping.NPJ Parkinson's disease · 2025Article
- Effects of deep brain stimulation of the nucleus accumbens and anterior limb of the internal capsule on heroin addiction: Over five years of long-term follow-up in a prospective open-label pilot study.Translational psychiatry · 2025Article
- The interplay between pulse width and activation depth in TENS: a computational study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Predictive modeling of evoked intracranial EEG response to medial temporal lobe stimulation in patients with epilepsy.Communications biology · 2024Article
- Article
- Kinematic Effects of Combined Subthalamic and Dorsolateral Nigral Deep Brain Stimulation in Parkinson's Disease.Journal of Parkinson's disease · 2024Article
- Neuromodulation of the anterior thalamus: Current approaches and opportunities for the future.Current research in neurobiology · 2023Review
- Short pulse and directional thalamic deep brain stimulation have differential effects in parkinsonian and essential tremor.Scientific reports · 2022Article
- Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation.Journal of neural engineering · 2022Article
- Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches.Frontiers in neurology · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundAchieving deep brain stimulation (DBS) dose equivalence is challenging, especially with pulse width tuning and directional contacts. Further, the precise effects of pulse width tuning are unknown, and recent reports of the effects of pulse width tuning on neural selectivity are at odds with classic biophysical studies.
methodsWe created multicompartment neuron models for two axon diameters and used finite element modeling to determine extracellular influence from standard and segmented electrodes. We analyzed axon activation profiles and calculated volumes of tissue activated.
resultsWe find that long pulse widths focus the stimulation effect on small, nearby fibers, suppressing distant white matter tract activation (responsible for some DBS side effects) and improving battery utilization when equivalent activation is maintained for small axons. Directional leads enable similar benefits to a greater degree. Reexamining previous reports of short pulse stimulation reducing side effects, we explore a possible alternate explanation: non-dose equivalent stimulation may have resulted in reduced spread of neural activation. Finally, using internal capsule avoidance as an example in the context of subthalamic stimulation, we present a patient-specific model to show how long pulse widths could help increase the biophysical therapeutic window. DISCUSSION: We find agreement with classic studies and predict that long pulse widths may focus the stimulation effect on small, nearby fibers and improve power consumption. While future pre-clinical and clinical work is necessary regarding pulse width tuning, it is clear that future studies must ensure dose equivalence, noting that energy- and charge-equivalent amplitudes do not result in equivalent spread of neural activation when changing pulse width.
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