ArticleJACC. Heart failure2020
Differential Associations of Chronic Inflammatory Diseases With Incident Heart Failure.
Article in JACC. Heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2026Guideline
- Human Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-Analysis of Prospective Studies.Journal of acquired immune deficiency syndromes (1999) · 2021Pooled it
- The risk of organ-based comorbidities in psoriasis: a systematic review and meta-analysis.Anais brasileiros de dermatologiaPooled it
- Trial
- Relationship of Vitamin D, Spondyloarthritis Activity and Left Ventricular Systolic and Diastolic Function.Journal of clinical medicine · 2026Article
- Microbiota-derived metabolites and cardiovascular implications in Inflammatory Bowel Disease (IBD).Molecular medicine (Cambridge, Mass.) · 2026Review
- Research on the effect of augmented reality based sensory interaction device in rehabilitation training of patients with chronic heart failure.BMC cardiovascular disorders · 2026Article
- Heart Failure Risk in Patients With Systemic Autoimmune Inflammatory Diseases.Journal of the American Heart Association · 2026Article
- Sodium Glucose Co-Transporter-2 inhibitors in patients with systemic sclerosis with or without heart failure.The American journal of medicine · 2026Article
- Association of inflammatory bowel disease with cardiovascular disease, and the mediating role of inflammation: a matched-cohort study.Therapeutic advances in gastroenterology · 2026Article
- Redox Regulation of Microvascular Physiology and Pathophysiology: Insights into Therapeutic Strategies and Limitations.Antioxidants & redox signaling · 2025Review
- Acute Immune Cell Dynamics During Myocardial Infarction and Their Association with Mortality.International journal of molecular sciences · 2025Article
- Impact of High Intensity Contact Physical Activity During a Match on Echocardiographic Parameters and High-Sensitivity Troponin I in Competitive Rugby Players.Journal of clinical medicine · 2025Article
- Autoimmune inflammation as a key risk factor for heart failure with preserved ejection fraction: the different types of inflammation driving to HFpEF.Frontiers in medicine · 2025Review
- Human immunology of heart failure: deconstructing inflammatory risk.European heart journal · 2024Article
- Risk of heart failure in inflammatory bowel disease: a Swedish population-based study.European heart journal · 2024Article
- Left ventricular systolic function assessed by standard and advanced echocardiographic techniques in patients with systemic lupus erythematosus: A systemic review and meta-analysis.Archives of rheumatology · 2024Review
- Heart failure with preserved ejection fraction and atrial fibrillation: clinical management in the context of recent therapeutic advances in heart failure and electrophysiology.Frontiers in cardiovascular medicine · 2024Review
- Article
- Inflammatory bowel disease and cardiac function: a systematic review of literature with meta-analysis.Therapeutic advances in gastroenterology · 2024Article
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe purpose of this study was to compare the risks of incident heart failure (HF) among a variety of chronic inflammatory diseases (CIDs) and to determine whether risks varied by severity of inflammation within each CID.
backgroundIndividuals with CIDs are at elevated risk for cardiovascular diseases, but data are limited regarding risk for HF.
methodsAn electronic health records database from a large urban medical system was examined, comparing individuals with CIDs with frequency-matched controls without CIDs, all of whom were receiving regular outpatient care. Rates of incident HF were determined by using the Kaplan-Meier method and subsequently used multivariate-adjusted proportional hazards models to compare HF risks for each CID. Exploratory analyses determined HF risks by proxy measurement of CID severity.
resultsOf 37,636 patients (n = 18,278 patients with CIDs; and n = 19,358 controls without CIDs) there were 960 incident HF cases over a median of 3.6 years. Risks for incident HF were significantly or borderline significantly elevated for patients with systemic sclerosis (hazard ratio [HR]: 7.26; 95% confidence interval [CI]: 5.72 to 9.21; p < 0.01), systemic lupus erythematosus (HR: 3.15; 95% CI: 2.41 to 4.11; p < 0.01), rheumatoid arthritis (HR: 1.39; 95% CI: 1.13 to 1.71; p < 0.01), and human immunodeficiency virus (HR: 1.28; 95% CI: 0.99 to 1.66; p = 0.06). There was no association between psoriasis or inflammatory bowel disease and incident HF, although patients with those CIDs with higher levels of C-reactive protein had higher risks for HF than controls.
conclusionsSystemic sclerosis and systemic lupus erythematosus were associated with the highest risks of HF, followed by rheumatoid arthritis and HIV. Measurements of inflammation were associated with HF risk across different CIDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.