Evidence map›Paper›PMID 32278670›Full record

ArticleAnaesthesia, critical care & pain medicine2020

SARS-CoV-2 in Spanish Intensive Care Units: Early experience with 15-day survival in Vitoria.

Helena Barrasa, Jordi Rello, Sofia Tejada, Alejandro Martín, Goiatz Balziskueta, Cristina Vinuesa, Borja Fernández-Miret, Ana Villagra, Ana Vallejo, Ana San Sebastián and 5 more

Registry-linked trialOpen access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Anaesthesia, critical care & pain medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04896866 (Efficacy and Safety of Antimicrobial Stewardship Intervention in Hospitalized COVID-19 Patients), which is not on this map. Cited by 124 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 25 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04896866 nacompletednot on this mapstarted 2021, after this paper: background citation

Efficacy and Safety of Antimicrobial Stewardship Intervention in Hospitalized COVID-19 Patients: A Pragmatic Clinical Trial

TypeinterventionalSponsorUniversity of AlbertaRan2021 to 2021Enrolled833ConditionsCovid19, COVID-19 Pneumonia, COVID-19 Lower Respiratory Infection, COVID-19 Acute Respiratory Distress SyndromeArmsAntimicrobial stewardship prospective audit and feedback
3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 25 syntheses or guidelines pooled it, 219 citations in OpenAlex.

  1. Recent Advance Analysis of Recovery in Hospitalized People with COVID-19: A Systematic Review.International journal of environmental research and public health · 2022
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  8. Case fatality rate of COVID-19: a systematic review and meta-analysis.Journal of preventive medicine and hygiene · 2021
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  12. Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021
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  17. Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020
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  18. Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Helena BarrasaCritical Care Department, Hospital Universitario de Alava, Spain.
Jordi RelloCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos II, Madrid, Spain; Clinical Research in Pneumonia & Sepsis (CRIPS), Vall d'Hebron Institute of Research, Barcelona, Spain; Clinical Research, CHU Nîmes, University Montpellier - Nîmes, Nîmes, France.
Sofia TejadaCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos II, Madrid, Spain; Clinical Research in Pneumonia & Sepsis (CRIPS), Vall d'Hebron Institute of Research, Barcelona, Spain. Electronic address: stmagraner@gmail.com.
Alejandro MartínCritical Care Department, Hospital Universitario de Alava, Spain.
Goiatz BalziskuetaCritical Care Department, Hospital Universitario de Alava, Spain.
Cristina VinuesaCritical Care Department, Hospital Universitario de Alava, Spain.
Borja Fernández-MiretCritical Care Department, Hospital Universitario de Alava, Spain.
Ana VillagraCritical Care Department, Hospital Universitario de Alava, Spain.
Ana VallejoCritical Care Department, Hospital Universitario de Alava, Spain.
Ana San SebastiánCritical Care Department, Hospital Universitario de Alava, Spain.
Sara CabañesCritical Care Department, Hospital Universitario de Alava, Spain.
Sebastián IribarrenCritical Care Department, Hospital Universitario de Alava, Spain.
Fernando FonsecaCritical Care Department, Hospital Universitario de Alava, Spain.
Javier MaynarCritical Care Department, Hospital Universitario de Alava, Spain.
Alava COVID-19 Study Investigators
Hospital Universitario Araba · ESCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESVall d'Hebron Institut de Recerca · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCommunity transmission of SARS-CoV-2 was detected in Spain in February 2020, with 216% intensive care unit (ICU) capacity expanded in Vitoria by March 18

methodsWe identified patients from the two public hospitals in Vitoria who were admitted to ICU with confirmed infection by SARS-CoV-2. Data reported here were available in April 6th, 2020. Mortality was assessed in those who completed 15-days of ICU stay.

resultsWe identified 48 patients (27 males) with confirmed SARS-CoV-2. Median [interquartile range (IQR)] age of patients was 63 [51-75] years. Symptoms began a median of 7 [5-12] days before ICU admission. The most common comorbidities identified were obesity (48%), arterial hypertension (44%) and chronic lung disease (37%). All patients were admitted by hypoxemic respiratory failure and none received non-invasive mechanical ventilation. Forty-five (94%) underwent intubation, 3 (6%) high flow nasal therapy (HFNT), 1 (2%) extracorporeal membrane oxygenation (ECMO) and 22 (46%) required prone position. After 15 days, 14/45 (31%) intubated patients died (13% within one week), 10/45 (22%) were extubated, and 21/45 (47%) underwent mechanical ventilation. Six patients had documented super-infection. Procalcitonin plasma above 0.5μg/L was associated with 16% vs. 19% (p=0.78) risk of death after 7 days.

conclusionThis early experience with SARS-CoV-2 in Spain suggests that a strategy of right oxygenation avoiding non-invasive mechanical ventilation was life-saving. Seven-day mortality in SARS-CoV-2 requiring intubation was lower than 15%, with 80% of patients still requiring mechanical ventilation. After 15 days of ICU admission, half of patients remained intubated, whereas one third died.

Indexed as

BetacoronavirusPandemicsAdultAgedAged, 80 and overAntiviral AgentsCombined Modality TherapyComorbidityCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentDisease OutbreaksFemaleHospital MortalityHospitals, PublicHumansAntiviral AgentsProcalcitoninARDSCOVID-19PneumoniaProcalcitonin

Identifiers

PMID32278670
PMCPMC7144603
OpenAlexW3015303791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.