ArticleThe American journal of cardiology2020
Contemporary Trends in Native Valve Infective Endocarditis in United States (from the National Inpatient Sample Database).
Article in The American journal of cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Native Aortic Valve Endocarditis Caused by Gut Bacterial Translocation Following Gastroenteritis.Cureus · 2025Article
- Clinical features and outcomes of infective endocarditis in persons experiencing homelessness.Infectious diseases of poverty · 2025Article
- The effects of spondylodiscitis on the inflammation burden in infective endocarditis.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2024Article
- In Plain Sight: The Need for a Dedicated Cardiovascular Infectious Disease Subspecialty.JACC. Advances · 2024Article
- Trends in Infective Endocarditis Mortality in the United States: 1999 to 2020: A Cause for Alarm.Journal of the American Heart Association · 2023Article
- Comparison of trends and outcomes of infective endocarditis in patients with versus without leukemia, 2002 to 2017, from a nationwide inpatient sample.Proceedings (Baylor University. Medical Center) · 2023Article
- Different drugs, different sides: injection use of opioids alone, and not stimulants alone, predisposes to right-sided endocarditis.Open heart · 2022Article
- Infective Endocarditis: Still More Challenges Than Convictions.Arquivos brasileiros de cardiologia · 2022Article
- Insight into the epidemiology of infective endocarditis in Portugal: a contemporary nationwide study from 2010 to 2018.BMC cardiovascular disorders · 2021Article
- Clinical outcomes in patients with native valve infective endocarditis and diabetes mellitus.World journal of cardiology · 2021Article
- Infective endocarditis at a tertiary-care hospital in China.Journal of cardiothoracic surgery · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Infective Endocarditis (IE) is associated with high mortality and morbidity. The data on contemporary trends and health care utilization remain scarce for IE. Consequently, we used the National Inpatient Sample database from 2002 to 2016 to study burden of IE. Risk-adjusted rates were calculated using an Analysis of Covariance with the Generalized Linear Model. Trends were assessed with linear regression and Pearson's Chi-square modeling, where appropriate. Binomial logistic regression was used for computing predictors of in-hospital mortality. We identified 523,432 hospitalizations for native valve IE. Risk-adjusted mortality decreased from 16.7% in 2002 to 9.7% in 2016 (p <0.01). The risk-adjusted length of stay decreased from 17.4 days in 2002 to 13.4 days in 2016 (p <0.01). Mean cost of stay adjusted for risk factors and inflation increased from 112,702$ in 2002 to 164,767$ in 2016 (p <0.01). Valve replacement increased from 10.2% in 2002 in to 13.4% in 2016, (p <0.01). Independent predictors of mortality included age (OR, 1.02 [1.02 to 1.020], p <0.01), female gender (OR, 1.07 [1.05 to 1.09], p <0.01), Blacks (OR, 1.28 [1.24 to 1.31], p <0.01), Hispanics (OR, 1.15 [1.11 to 1.19], p <0.01) and patients with co-morbid conditions like congestive heart failure (OR, 1.78 [1.74 to 1.82], p <0.01), renal failure (OR, [1.69 [1.65 to 1.73], p <0.01) and weight loss (OR, 1.40 [1.36 to 1.43], p <0.01). In summary, in-hospital mortality from native valve IE has been decreasing but total hospitalization and average cost of stay has increased.
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