Evidence map›Paper›PMID 32278312›Full record

ReviewCurrent opinion in insect science2020

Exploiting insect-specific viruses as a novel strategy to control vector-borne disease.

Edward I Patterson, Jandouwe Villinger, Joseph N Muthoni, Lucien Dobel-Ober, Grant L Hughes

Open access · bronzeAbstract readReview
In one paragraph

Review in Current opinion in insect science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.

  1. Pooled it
  2. Exploring the Mosquito-Arbovirus Network: A Survey of Vector Competence Experiments.The American journal of tropical medicine and hygiene · 2023
    Pooled it
  3. Article
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  10. RNA sequencing analysis of viromes ofProceedings of the National Academy of Sciences of the United States of America · 2025
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  14. Review
  15. The diversity of viral community inFrontiers in microbiology · 2025
    Article
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  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Edward I PattersonCentre for Neglected Tropical Diseases, Departments of Vector Biology and Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK. Electronic address: ian.patterson@lstmed.ac.uk.
Jandouwe VillingerInternational Centre of Insect Physiology and Ecology (icipe), P.O. Box 30772-00100, Nairobi, Kenya.
Joseph N MuthoniInternational Centre of Insect Physiology and Ecology (icipe), P.O. Box 30772-00100, Nairobi, Kenya.
Lucien Dobel-OberCentre for Neglected Tropical Diseases, Departments of Vector Biology and Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
Grant L HughesCentre for Neglected Tropical Diseases, Departments of Vector Biology and Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
Liverpool School of Tropical Medicine · GBInternational Centre of Insect Physiology and Ecology · KE

Funding

Microbial interplay between ZIKA virus and the native microbiome in mosquitoesR21AI129507 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HUGHES, GRANT LESLIE · 2017 to 2018
$371k
Exploiting gnotobiotic systems to examine microbiota acquisition in mosquitoes and for microbiome transplantationsR21AI138074 · NIAID · TMLIVERPOOL SCHOOL OF TROPICAL MEDICINE · PI HUGHES, GRANT LESLIE · 2018 to 2019
$296k
Biotechnology and Biological Sciences Research Council BB/T001240/1NIAID NIH HHS R21 AI129507NIAID NIH HHS R21 AI138074
6 · The paper itself

Abstract

Novel insect-specific viruses (ISVs) are being discovered in many important vectors due to advances in sequencing technology and a growing awareness of the virome. Several in vitro and in vivo studies indicate that ISVs are capable of modulating pathogenic arboviruses. In addition, there is growing evidence that both vertical and horizonal transmission strategies maintain ISVs in vector populations. As such there is potential to exploit ISVs for stand-alone vector control strategies and deploying them in synergy with other symbiont control approaches such as Wolbachia-mediated control. However, before the applied potential can be realized, a greater understanding of their basic biology is required, including their species range, ability to be maintained and transmitted in native and non-native vector hosts, and the effect of infection on a range of pathogens.

Indexed as

Insect VirusesAedesAnimalsArbovirusesBiological Control AgentsFlavivirusFlavivirus InfectionsInsectaInsect ControlMosquito VectorsPhylogenyVector Borne DiseasesBiological Control Agents

Identifiers

PMID32278312
PMCPMC7302987
OpenAlexW3008316009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.