Evidence map›Paper›PMID 32278308›Full record

ArticlePregnancy hypertension2020

Placental endothelin-converting enzyme-1 is decreased in preeclampsia.

Anna McCormick, Jasmin Kristianto, Xiaohu Wang, Jennifer McIntosh, Meredith Cruz, Judith U Hibbard, Robert D Blank

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pregnancy hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anna McCormickMedical College of Wisconsin, Dept. Of Obstetrics and Gynecology, 9200 West Wisconsin Ave, Milwaukee, WI 53226, United States. Electronic address: anna_mccormick@rush.edu.
Jasmin KristiantoMedical College of Wisconsin, Dept. Of Obstetrics and Gynecology, 9200 West Wisconsin Ave, Milwaukee, WI 53226, United States.
Xiaohu WangMedical College of Wisconsin, Dept. Of Obstetrics and Gynecology, 9200 West Wisconsin Ave, Milwaukee, WI 53226, United States.
Jennifer McIntoshMedical College of Wisconsin, Dept. Of Obstetrics and Gynecology, 9200 West Wisconsin Ave, Milwaukee, WI 53226, United States.
Meredith CruzMedical College of Wisconsin, Dept. Of Obstetrics and Gynecology, 9200 West Wisconsin Ave, Milwaukee, WI 53226, United States.
Judith U HibbardMedical College of Wisconsin, Dept. Of Obstetrics and Gynecology, 9200 West Wisconsin Ave, Milwaukee, WI 53226, United States.
Robert D BlankMedical College of Wisconsin, Dept. Of Obstetrics and Gynecology, 9200 West Wisconsin Ave, Milwaukee, WI 53226, United States.
Medical College of Wisconsin · US

Funding

Novel role for placental endothelial mitochondria in preeclampsiaK08HL150340 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MCINTOSH, JENNIFER J · 2020 to 2024
$754k
NHLBI NIH HHS K08 HL150340
6 · The paper itself

Abstract

Endothelin-converting enzyme-1(ECE-1) is a key regulatory enzyme in the processing of endothelin-1 (ET-1). We quantified and localized ECE-1 in normal and preeclamptic placentas. Normal (n=6) and preeclamptic (n=6) placentas were serially sectioned for immunofluorescence (IF). Cell type specific markers identified endothelial, trophoblast, macrophage, smooth muscle, and fibroblast cells. Quantitative analyses were performed by western blot and ELISA. IF identified ECE-1 expression within the stroma and villous space. Cellular localization of ECE-1 was limited to endothelial membranes. There was significantly less ECE-1 in preeclamptic placentas, suggesting ECE-1 is important for proper regulation of ET-1 within the placenta.

Indexed as

AdultBiomarkersCase-Control StudiesChorionic VilliDown-RegulationEndothelial CellsEndothelin-Converting EnzymesFemaleHumansPlacentaPre-EclampsiaPregnancyStromal CellsBiomarkersECE1 protein, humanEndothelin-Converting EnzymesEndothelial cellsEndothelinEndothelin-converting enzyme 1(ECE-1)PlacentaPreeclampsiaTrophoblast

Identifiers

PMID32278308
PMCPMC7532811
OpenAlexW3015549876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.