Evidence map›Paper›PMID 32278071›Full record

ArticleOsteoarthritis and cartilage2020

MRI evaluation of articular cartilage in patients with juvenile osteochondritis dissecans (JOCD) using T2∗ mapping at 3T.

K D Ludwig, C P Johnson, Š Zbýň, A Nowacki, S Marette, T Takahashi, J A Macalena, B J Nelson, M A Tompkins, C S Carlson and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Naturally occurring osteochondrosis latens lesions identified by quantitative and morphological 10.5 T MRI in pigs.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  5. Article
  6. Compositional evaluation of lesion and parent bone in patients with juvenile osteochondritis dissecans of the knee using TJournal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

K D LudwigCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
C P JohnsonCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
Š ZbýňCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
A NowackiCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
S MaretteDepartment of Radiology, University of Minnesota, Minneapolis, MN, USA.
T TakahashiDepartment of Radiology, University of Minnesota, Minneapolis, MN, USA.
J A MacalenaDepartment of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN, USA.
B J NelsonDepartment of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN, USA; TRIA Orthopaedic Center, Minneapolis, MN, USA.
M A TompkinsDepartment of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN, USA; TRIA Orthopaedic Center, Minneapolis, MN, USA.
C S CarlsonDepartment of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, USA.
J M EllermannCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, University of Minnesota, Minneapolis, MN, USA. Electronic address: eller001@umn.edu.
University of Minnesota · US

Funding

NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Musculoskeletal Training GrantT32AR050938 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CLOHISY, DENIS R · 2004 to 2020
$3.0M
Novel MRI Methods for Osteochondritis Dissecans (OCD) / Osteochondrosis (OC)R01AR070020 · NIAMS · UNIVERSITY OF MINNESOTA · PI CARLSON, CATHY S., ELLERMANN, JUTTA M · 2017 to 2021
$2.4M
Ultrahigh-Field MRI of Hip Joint Diseases Leading to Early OsteoarthritisK01AR070894 · NIAMS · UNIVERSITY OF MINNESOTA · PI JOHNSON, CASEY PETER · 2017 to 2021
$649k
NIAMS NIH HHS K01 AR070894NIAMS NIH HHS R01 AR070020NIAMS NIH HHS T32 AR050938NIBIB NIH HHS P41 EB015894
6 · The paper itself

Abstract

objectiveEvaluate articular cartilage by magnetic resonance imaging (MRI) T2∗ mapping within the distal femur and proximal tibia in adolescents with juvenile osteochondritis dissecans (JOCD).

designJOCD imaging studies acquired between August 2011 and February 2019 with clinical and T2∗ mapping MRI knee images were retrospectively collected and analyzed for 31 participants (9F/22M, 15.0 ± 3.8 years old) with JOCD lesions in the medial femoral condyle (MFC). In total, N = 32 knees with JOCD lesions and N = 14 control knees were assessed. Mean T2∗ values in four articular cartilage regions-of-interest (MFC, lateral femoral condyle (LFC), medial tibia (MT), and lateral tibia (LT)) and lesion volume were measured and analyzed using Wilcoxon-rank-sum tests and Spearman correlation coefficients (R).

resultsMean ± standard error T2∗ differences observed between the lesion-sided MFC and the LFC in JOCD-affected knees (28.5 ± 0.9 95% confidence interval [26.8, 30.3] vs 26.3 ± 0.7 [24.8, 27.7] ms, P = 0.088) and between the affected- and control-knee MFC (28.5 ± 0.9 [26.8, 30.3] vs 28.5 ± 0.6 [27.1, 29.9] ms, P = 0.719) were nonsignificant. T2∗ was significantly increased in the lesion-sided MT vs the LT for the JOCD-affected knees (21.5 ± 0.7 [20.1, 22.9] vs 18.0 ± 0.7 [16.5, 19.5] ms, P = 0.002), but this same difference was also observed between the MT and LT in control knees (21.0 ± 0.6 [19.7, 22.3] vs 18.1 ± 1.1 [15.8, 20.4] ms, P = 0.037). There was no significant T2∗ difference between the affected- and control-knee MT (21.5 ± 0.7 [20.1, 22.9] vs 21.0 ± 0.6 [19.7, 22.3] ms, P = 0.905). T2∗ within the lesion-sided MFC was not correlated with patient age (R = 0.20, P = 0.28) or lesion volume (R = 0.06, P = 0.75). T2∗ values were slightly increased near lesions in later-stage JOCD subjects but without statistical significance.

conclusionsT2∗ relaxations times were not significantly different from control sites in the articular cartilage overlying JOCD lesions in the MFC or adjacent MT cartilage in early-stage JOCD.

Indexed as

AdolescentAge of OnsetCartilage, ArticularChildFemaleFemurHumansKnee JointMagnetic Resonance ImagingMaleOsteochondritis DissecansRetrospective StudiesTibiaYoung AdultArticular cartilageJuvenile osteochondritis dissecansMagnetic resonance imagingQuantitative imagingT2∗ relaxometry

Identifiers

PMID32278071
PMCPMC8576840
OpenAlexW3016017370

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.