ReviewThe European journal of neuroscience2021
Complementary roles of differential medial entorhinal cortex inputs to the hippocampus for the formation and integration of temporal and contextual memory (Systems Neuroscience).
Review in The European journal of neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Neuroanatomical and psychological considerations in temporal lobe epilepsy.Frontiers in neuroanatomy · 2022Pooled it
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Exploring the Expression Changes of Immune Genes in Alzheimer's Disease: A Study on ANXA1, VCAM1, and CCL2.Molecular neurobiology · 2026Article
- Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons.Frontiers in aging neuroscience · 2026Review
- Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia.Alzheimer's research & therapy · 2025Article
- Quantitative simulation of near-infrared light treatment for Alzheimer's disease using patient-individualized optical-parametric phantoms.Neurophotonics · 2025Article
- Overabundant endocannabinoids in neurons are detrimental to cognitive function.bioRxiv : the preprint server for biology · 2024Article
- Understanding Others' Distress Through Past Experiences: The Role of Memory Engram Cells in Observational Fear.Advances in neurobiology · 2024Review
- How the forebrain transitions to adulthood: developmental plasticity markers in a long-lived rodent reveal region diversity and the uniqueness of adolescence.Frontiers in neuroscience · 2024Article
- Heterogenous effect of early adulthood stress on cognitive aging and synaptic function in the dentate gyrus.Frontiers in molecular neuroscience · 2024Article
- Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults.iScience · 2023Article
- Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum.Neuroscience and biobehavioral reviews · 2023Review
- Dissecting cell-type-specific pathways in medial entorhinal cortical-hippocampal network for episodic memory.Journal of neurochemistry · 2023Review
- Article
- Article
- Neuronal Ensembles Organize Activity to Generate Contextual Memory.Frontiers in behavioral neuroscience · 2022Review
- Entorhinal cortical Island cells regulate temporal association learning with long trace period.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Different Modulatory Effects of Cognitive Training and Aerobic Exercise on Resting State Functional Connectivity of Entorhinal Cortex in Community-Dwelling Older Adults.Frontiers in aging neuroscience · 2021Article
- Lateral entorhinal cortex neurons that project to nucleus accumbens mediate contextual associative memory.Learning & memory (Cold Spring Harbor, N.Y.)Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In humans and rodents, the entorhinal cortical (EC)-hippocampal (HPC) circuit is crucial for the formation and recall of memory, preserving both spatial information and temporal information about the occurrence of past events. Both modeling and experimental studies have revealed circuits within this network that play crucial roles in encoding space and context. However, our understanding about the time-related aspects of memory is just beginning to be understood. In this review, we first describe updates regarding recent anatomical discoveries for the EC-HPC network, as several important neural circuits critical for memory formation have been discovered by newly developed neural tracing technologies. Second, we examine the complementary roles of multiple medial entorhinal cortical inputs, including newly discovered circuits, into the hippocampus for the temporal and spatial aspects of memory. Finally, we will discuss how temporal and contextual memory information is integrated in HPC cornu ammonis 1 cells. We provide new insights into the neural circuit mechanisms for anatomical and functional segregation and integration of the temporal and spatial aspects of memory encoding in the EC-HPC networks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.