Evidence map›Paper›PMID 32277437›Full record

ArticleAging clinical and experimental research2021

Uric acid and late-onset Alzheimer's disease: results from the ReGAl 2.0 project.

Virginia Boccardi, Silvia Carino, Elisa Marinelli, Maria Lapenna, Giulia Caironi, Anna Rita Bianco, Roberta Cecchetti, Carmelinda Ruggiero, Patrizia Mecocci, ReGAl 2.0 Study Group:

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In one paragraph

Article in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Virginia BoccardiInstitute of Gerontology and Geriatrics, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy. virginia.boccardi@unipg.it.
Silvia CarinoInstitute of Gerontology and Geriatrics, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.
Elisa MarinelliInstitute of Gerontology and Geriatrics, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.
Maria LapennaInstitute of Gerontology and Geriatrics, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.
Giulia CaironiInstitute of Gerontology and Geriatrics, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.
Anna Rita BiancoInstitute of Gerontology and Geriatrics, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.
Roberta CecchettiInstitute of Gerontology and Geriatrics, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.
Carmelinda RuggieroInstitute of Gerontology and Geriatrics, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.
Patrizia MecocciInstitute of Gerontology and Geriatrics, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.
ReGAl 2.0 Study Group:
University of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been suggested that oxidative stress may have a role in the pathogenesis of Alzheimer's disease (AD). Serum uric acid (UA) could exert neuroprotective effects via its antioxidant capacities. Many studies investigated serum UA levels in subjects with AD, but to date, results are conflicting and evidence in old age subjects is weak.

aimsIn this study, we assess whether serum UA levels would be altered in the AD old age subjects compared to those of initial cognitive impairment and healthy controls.

methodsThis is a retrospective study with data gathered from the ReGAl 2.0 project (Rete Geriatrica Alzheimer-Geriatric Network on Alzheimer's disease), a large Italian multicentric clinical-based study. A cohort of 232 subjects, including 65 (healthy controls HC), 95 mild cognitive impairment (MCI), and 72 AD, were included in the study. Serum UA was measured in all subjects by routine laboratory method.

resultsThe sample population includes 232 subjects, mostly women with a mean age of 79.16 ± 5.64 (range 66-93) years. No significant difference was found in gender distribution between groups. No significant correlation was found in all populations between age and uric acid levels. AD group had significantly lower UA levels as compared with HC. The association of uric acid with AD presence after adjusting for age, gender, body mass index (BMI) and creatinine levels showed that uric acid level was independently associated with the diagnosis of AD.

conclusionsThese data indicate that serum UA is reduced in AD, supporting that UA may have a potential protective role against AD in old age.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedAged, 80 and overBiomarkersFemaleHumansItalyRetrospective StudiesUric AcidBiomarkersUric AcidAgingAlzheimer’sOxidative stressPreventionUric acid

Identifiers

PMID32277437
OpenAlexW3016224953

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.