Evidence map›Paper›PMID 32277362›Full record

ReviewGenes & genomics2020

Molecular fossils "pseudogenes" as functional signature in biological system.

Rajesh Kumar Singh, Divya Singh, Arpana Yadava, Akhileshwar Kumar Srivastava

Abstract readReview
PubMed Publisher
In one paragraph

Review in Genes & genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rajesh Kumar SinghInstitute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Divya SinghDepartment of Chemical Engineering and Technology IIT, BHU, Varanasi, 221005, India.
Arpana YadavaDepartment of Chemical Engineering and Technology IIT, BHU, Varanasi, 221005, India.
Akhileshwar Kumar SrivastavaDepartment of Botany, Banaras Hindu University, Varanasi, 221005, India. akhileshwar.kumar2@gmail.com.
Banaras Hindu University · INIndian Institute of Technology BHU · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pseudogenes have been known as non-functional molecular relics developed from inactivated genomic mutations while evolution. However, they have a various function at distinct molecular stages (DNA, RNA and protein) in different biological events including in cancer and associated with parental-gene-dependently and parental-gene independently. The interactions of pseudogenes with ancestor genes or other genes alter in their sequences and transcriptional processes. Pseudogene of RNA sequences have multiple functions in post-transcriptional activities as antisense RNAs, endogenous small-interference RNAs, and competing endogenous RNAs. Moreover, it also plays vital roles in controlling of its parent genes and other pseudogenes transcribing into RNA. Pseudogene transcripts make small interfering RNA or decline cellular miRNA level. The current review focuses on pseudogene functional signature in human genome by regulating the gene expression.

Indexed as

Evolution, MolecularPseudogenesAnimalsHumansRNA, UntranslatedRNA, UntranslatedCancerGene expressionNoncoding RNAPseudogenesRNATranscription

Identifiers

PMID32277362
OpenAlexW3016253140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.