Evidence map›Paper›PMID 32277328›Full record

ArticleJournal of natural medicines2020

Trypanocidal and leishmanicidal activity of six limonoids.

Dietmar Steverding, Lazare S Sidjui, Éden Ramalho Ferreira, Bathelemy Ngameni, Gabriel N Folefoc, Valérie Mahiou-Leddet, Evelyne Ollivier, G Richard Stephenson, Thomas E Storr, Kevin M Tyler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural medicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Plant-Derived Terpenes as Emerging Therapeutics Against Schistosomiasis.International journal of molecular sciences · 2026
    Review
  2. Article
  3. AnHeliyon · 2024
    Article
  4. Article
  5. Plant Terpenoids as Hit Compounds against Trypanosomiasis.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  6. Pharmaceutical biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dietmar SteverdingBob Champion Research and Education Building, Norwich Medical School, University of East Anglia, Norwich, NR4 7UQ, UK. dsteverding@hotmail.com.
Lazare S SidjuiInstitute of Medical Research and Medicinal Plant Studies, P.O. Box 13033, Yaoundé, Cameroon.
Éden Ramalho FerreiraBioMedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK.
Bathelemy NgameniDepartment of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Science, University of Yaoundé I, Yaoundé, Cameroon. bath_ngameni@yahoo.fr.
Gabriel N FolefocBioorganic and Medicinal Chemistry Laboratory, Department of Organic Chemistry, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Valérie Mahiou-LeddetAix-Marseille University, Avignon University, CNRS, IRD, IMBE, FAC PHARM, Marseille, France.
Evelyne OllivierAix-Marseille University, Avignon University, CNRS, IRD, IMBE, FAC PHARM, Marseille, France.
G Richard StephensonSchool of Chemistry, University of East Anglia, Norwich, NR4 7TJ, UK.
Thomas E StorrSchool of Chemistry, University of East Anglia, Norwich, NR4 7TJ, UK.
Kevin M TylerBioMedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Six limonoids [kotschyienone A and B (1, 2), 7-deacetylgedunin (3), 7-deacetyl-7-oxogedunin (4), andirobin (5) and methyl angolensate (6)] were investigated for their trypanocidal and leishmanicidal activities using bloodstream forms of Trypanosoma brucei and promastigotes of Leishmania major. Whereas all compounds showed anti-trypanosomal activity, only compounds 1-4 displayed anti-leishmanial activity. The 50% growth inhibition (GI

Indexed as

AnimalsHL-60 CellsHumansLeishmania majorLeishmaniasisLimoninsMicrobial Sensitivity TestsTrypanocidal AgentsTrypanosoma brucei bruceiTrypanosomiasisLimoninsTrypanocidal AgentsAfrican trypanosomiasisLeishmania majorLeishmaniasisLimonoidsTrypanosoma brucei

Identifiers

PMID32277328
PMCPMC7253382

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.