ArticleExperimental & applied acarology2020
RNAi of the nuclear receptor HR3 suggests a role in the molting process of the spider mite Panonychus citri.
Article in Experimental & applied acarology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Fusion dsRNA targeting ecdysteroid signaling provides efficient and selective RNAi-based control of spider mites.Pest management science · 2026Article
- Knockdown of farnesyl pyrophosphate synthetase gene TuFPPS by RNAi extends quiescent period and halts molting of the spider mite, Tetranychus urticae.Experimental & applied acarology · 2025Article
- RNA interference knockdown of the nuclear receptor HR3 suppresses vitellogenesis in Chilo suppressalis.Molecular biology reports · 2025Article
- Ecdysteroid Biosynthesis Halloween GeneInternational journal of molecular sciences · 2023Article
- Transcriptome Analysis of Hormone-and Cuticle-Related Genes in the Development Process of Deutonymph inInsects · 2021Article
- Genome-Wide Characterization and Identification of Long Non-Coding RNAs during the Molting Process of a Spider Mite,International journal of molecular sciences · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Ecdysteroids regulate molting in arthropods by binding to heterodimers of the ecdysone receptor and retinoid-X-receptor, homologous to the ultraspiracle protein, to induce the expression of downstream signal response genes including the nuclear receptor HR3. However, the detailed expression dynamics of HR3 during molting in spider mites are not yet clear. In this study, the full length of PcHR3 was retrieved based on the genome of citrus red mite, Panonychus citri. The open reading frame is 1707 bp encoding 568 amino acids, which contains a DNA binding domain and a ligand binding domain. Then, the expression pattern of PcHR3 was analyzed throughout the development of the deutonymph by RT-qPCR. The result showed that PcHR3 was mainly transcribed in the late deutonymph stage, when the deutonymph was at least 24 h old and motionless, the critical point at which the mites started molting. Transcription reached the highest level in 32-h-old deutonymphs and decreased by 36 h, where the mites remained in a quiescent state. Further silencing of PcHR3 by leaf-disc-based delivery of dsRNA to 8-h-old deutonymph mites, resulted in retarded development and death of 58% of deutonymphs. In summary, we suggest that PcHR3 regulates the latter stages of molting in P. citri.
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