Evidence map›Paper›PMID 32277266›Full record

ArticleArchives of toxicology2020

Exposure to inorganic arsenic and its methylated metabolites alters metabolomics profiles in INS-1 832/13 insulinoma cells and isolated pancreatic islets.

Yuan-Yuan Li, Christelle Douillet, Madelyn Huang, Rowan Beck, Susan Jenkins Sumner, Miroslav Styblo

Open access · greenAbstract read
In one paragraph

Article in Archives of toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  4. Exploring the toxicological network in diabetic microvascular disease.International journal of surgery (London, England) · 2025
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  7. Characterizing the metabolic response of the zebrafish kidney to overfeeding.American journal of physiology. Renal physiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yuan-Yuan LiDepartment of Nutrition, Nutrition Research Institute, CB# 74612, University of North Carolina at Chapel Hill School of Public Health, Chapel Hill, NC, 27599-7461, USA.
Christelle DouilletDepartment of Nutrition, CB# 74612, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, 27599-7461, USA.
Madelyn HuangCurriculum in Toxicology and Environmental Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA.
Rowan BeckCurriculum in Genetics and Molecular Biology, School of Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA.
Susan Jenkins SumnerDepartment of Nutrition, Nutrition Research Institute, CB# 74612, University of North Carolina at Chapel Hill School of Public Health, Chapel Hill, NC, 27599-7461, USA. Susan_sumner@unc.edu.
Miroslav StybloDepartment of Nutrition, CB# 74612, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, 27599-7461, USA. styblo@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Venkata Saroja Voruganti · 1999 to 2026
$31.6M
The UNC Chapel Hill Superfund Research Program (UNC-SRP)P42ES031007 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Gray · 2020 to 2026
$22.2M
RTI's Regional Comprehensive Metabolomics Resource CenterU24DK097193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUMNER, SUSAN J · 2012 to 2017
$9.8M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Humanized mouse models for arsenic toxicologyR01ES032643 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KOLLER, BEVERLY H, STYBLO, MIROSLAV · 2021 to 2025
$2.1M
Mechanisms of Arsenic-Induced Diabetes Mellitus - Administrative SupplementR01ES022697 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STYBLO, MIROSLAV · 2014 to 2017
$1.5M
National Institutes of Health (US) 1U24DK097193NIDDK NIH HHS DK056350NIDDK NIH HHS P30 DK056350NIDDK NIH HHS U24 DK097193NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P42 ES031007NIEHS NIH HHS R01 ES022697NIEHS NIH HHS R01ES022697NIEHS NIH HHS R01 ES032643NIGMS NIH HHS T32 GM007092
6 · The paper itself

Abstract

Inorganic arsenic (iAs) is an environmental diabetogen, but mechanisms underlying its diabetogenic effects are poorly understood. Exposures to arsenite (iAs

Indexed as

MetabolomeAdenosine TriphosphateAnimalsArsenitesBiotransformationCacodylic AcidCell Line, TumorEnergy MetabolismInsulinomaIslets of LangerhansMaleMetabolomicsMethylationMice, Inbred C57BLMitochondriaOxidative StressAdenosine TriphosphatearseniteArsenitesCacodylic Aciddimethylarsinous acidmethylarsoniteArsenicDiabetesMetabolomicsPancreatic isletsβ-Cells

Identifiers

PMID32277266
PMCPMC8711643
OpenAlexW3016025105

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.