Evidence map›Paper›PMID 32277232›Full record

ArticleScientific reports2020

Analysis of the receptor BCMA as a biomarker in systemic lupus erythematosus patients.

Diana Celeste Salazar-Camarena, Claudia Azucena Palafox-Sánchez, Alvaro Cruz, Miguel Marín-Rosales, José Francisco Muñoz-Valle

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Article
  3. The H159Y Variant of the BAFF-R Gene (International journal of molecular sciences · 2026
    Article
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  20. New biomarkers in SLE: from bench to bedside.Rheumatology (Oxford, England) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Diana Celeste Salazar-CamarenaResearch Institute in Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico.ORCID http://orcid.org/0000-0001-7814-0191
Claudia Azucena Palafox-SánchezResearch Institute in Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico. kklaumx@yahoo.com.ORCID http://orcid.org/0000-0003-0836-4186
Alvaro CruzResearch Institute in Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico.
Miguel Marín-RosalesDepartment of Rheumatology, West Medical Hospital, Ministry of Health, Zapopan, Mexico.
José Francisco Muñoz-ValleResearch Institute in Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico.
Universidad de Guadalajara · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) play central roles in B cell development and maturation. Soluble forms of their receptors can be generated by proteolytic cleavage; however, their physiological and clinical roles are unknown. This study aimed to assess the relationships between the receptor soluble B cell maturation antigen (sBCMA) and clinical variables in systemic lupus erythematosus (SLE) patients. Serum cytokine concentrations were measured by ELISA for 129 SLE patients and 34 healthy controls (HCs), and the expression of the receptor BCMA was evaluated on B and plasma cells from 40 subjects. SLE patients showed aberrant expression of the receptor BCMA on B and plasma cells. Soluble levels of the receptor sBCMA and its ligands sAPRIL and sBAFF were increased in SLE patients compared with HCs. Additionally, sBCMA (r

Indexed as

AdolescentAdultAgedB-Cell Activating FactorB-Cell Maturation AntigenBiomarkersCase-Control StudiesDNA-Binding ProteinsFemaleHealthy VolunteersHumansLupus Erythematosus, SystemicMaleMiddle AgedPredictive Value of TestsProspective StudiesB-Cell Activating FactorB-Cell Maturation AntigenBiomarkersDNA-Binding ProteinsPDS5B protein, humanTNFRSF17 protein, humanTNFSF13B protein, humanTranscription Factors

Identifiers

PMID32277232
PMCPMC7148319
OpenAlexW3015877373

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.