ArticleScientific reports2020
Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- From transporter to motor: Evolutionary and structural insights into the emergence of prestin's area-motor activity in mammals.Protein science : a publication of the Protein Society · 2026Article
- The cortilymph wave: Its relation to the traveling wave, auditory-nerve responses, and low-frequency downward glides.Hearing research · 2025Review
- Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Nanocomposite Hydrogels as Functional Extracellular Matrices.Gels (Basel, Switzerland) · 2023Review
- A parametric blueprint for optimum cochlear outer hair cell design.Journal of the Royal Society, Interface · 2023Article
- Coupling between outer hair cell electromotility and prestin sensor charge depends on voltage operating point.Hearing research · 2022Article
- Prestin-Mediated Frequency Selectivity Does not Cover Ultrahigh Frequencies in Mice.Neuroscience bulletin · 2022Article
- On the frequency response of prestin charge movement in membrane patches.Biophysical journal · 2022Article
- Single particle cryo-EM structure of the outer hair cell motor protein prestin.Nature communications · 2022Article
- Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- State dependent effects on the frequency response of prestin's real and imaginary components of nonlinear capacitance.Scientific reports · 2021Article
- The cochlear outer hair cell speed paradox.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Outer hair cell (OHC) nonlinear capacitance (NLC) represents voltage sensor charge movements of prestin (SLC26a5), the protein responsible for OHC electromotility. Previous measures of NLC frequency response have employed methods which did not assess the influence of dielectric loss (sensor charge movements out of phase with voltage) that may occur, and such loss conceivably may influence prestin's frequency dependent activity. Here we evaluate prestin's complex capacitance out to 30 kHz and find that prestin's frequency response determined using this approach coincides with all previous estimates. We also show that membrane tension has no effect on prestin's frequency response, despite substantial shifts in its voltage operating range, indicating that prestin transition rate alterations do not account for the shifts. The magnitude roll-off of prestin activity across frequency surpasses the reductions of NLC caused by salicylate treatments that are known to abolish cochlear amplification. Such roll-off likely limits the effectiveness of prestin in contributing to cochlear amplification at the very high acoustic frequencies processed by some mammals.
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