ArticleNeurology2020
In utero exposure to the Great Chinese Famine and risk of intracerebral hemorrhage in midlife.
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Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies.BMC medicine · 2023Pooled it
- Early-Life Exposure to the Chinese Famine of 1959-1961 and Type 2 Diabetes in Adulthood: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Unveiling the long-term impact: exploring the link between exposure to the great Chinese famine and health-related quality of life in middle-aged and elderly populations through propensity score matching.BMC public health · 2025Article
- Metabolic syndrome, high-sensitivity C-reactive protein and the risk of heart failure: the Kailuan cohort study.Frontiers in endocrinology · 2025Article
- Early-life famine exposure and subsequent risk of chronic disease comorbidity in later adulthood: the role of social activities.Frontiers in nutrition · 2025Article
- In utero and childhood exposure to the great Chinese famine and risk of aging in adulthood.Scientific reports · 2024Article
- Effect of In utero Exposure to Air Pollution on Adulthood Hospitalizations.Journal of urban health : bulletin of the New York Academy of Medicine · 2024Review
- Brachial-ankle pulse wave velocity is a stronger predictor than blood pressure for atherosclerotic cardiovascular diseases and all-cause mortality: a cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Metabolic Dysfunction-associated fatty liver disease and incident heart failure risk: the Kailuan cohort study.Diabetology & metabolic syndrome · 2023Article
- Long-Term Impact of the Great Chinese Famine on the Risks of Specific Arrhythmias and Severe Hypertension in the Offspring at an Early Stage of Aging.Journal of personalized medicine · 2023Article
- Effects of fetal famine exposure on the cardiovascular disease risk in the metabolic syndrome individuals.Diabetology & metabolic syndrome · 2022Article
- Low-Density Lipoprotein Cholesterol and the Risk of Rheumatoid Arthritis: A Prospective Study in a Chinese Cohort.Nutrients · 2022Article
- Sex Differences at Early Old Stage in Glycolipid Metabolism and Fatty Liver in Offspring Prenatally Exposed to Chinese Great Famine.Frontiers in nutrition · 2022Article
- Leukocyte as an Independent Predictor of Lower-Extremity Deep Venous Thrombosis in Elderly Patients With Primary Intracerebral Hemorrhage.Frontiers in neurology · 2022Article
- Early-Life Exposure to Malnutrition From the Chinese Famine on Risk of Asthma and Chronic Obstructive Pulmonary Disease in Adulthood.Frontiers in nutrition · 2022Article
- Association of Parental Famine Exposure With Offspring Depression and Cognition Function.Frontiers in psychiatry · 2022Article
- Alcohol Consumption and Risk of Rheumatoid Arthritis among Chinese Adults: A Prospective Study.Nutrients · 2021Article
- Maternal Undernutrition Modulates Neonatal Rat Cerebrovascular Structure, Function, and Vulnerability to Mild Hypoxic-Ischemic Injury via Corticosteroid-Dependent and -Independent Mechanisms.International journal of molecular sciences · 2021Article
- Ideal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study.Frontiers in cardiovascular medicine · 2021Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Yun LiFrom the Department of Preventive Medicine (Yun Li), School of Public Health, North China University of Science and Technology, Tangshan; Department of Nutritional Sciences (Yun Li, X.G.), Pennsylvania State University, State College; Department of Nutrition (Yanping Li), Harvard T.H. Chan School of Public Health; Department of Neurology (M.E.G.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Neurology (Y. Liu) and Cardiology (J.S., S.W.), Kailuan General Hospital, North China University of Science and Technology; Department of Neurosurgery (P.Y.), Affiliated Hospital of North China University of Science and Technology, Tangshan; Department of Neurology (S.Z.), The Second Affiliated Hospital of Soochow University, Suzhou, China; and Department of Nutrition Science (M.R.F.), Purdue University, West Lafayette, IN.
Yanping LiFrom the Department of Preventive Medicine (Yun Li), School of Public Health, North China University of Science and Technology, Tangshan; Department of Nutritional Sciences (Yun Li, X.G.), Pennsylvania State University, State College; Department of Nutrition (Yanping Li), Harvard T.H. Chan School of Public Health; Department of Neurology (M.E.G.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Neurology (Y. Liu) and Cardiology (J.S., S.W.), Kailuan General Hospital, North China University of Science and Technology; Department of Neurosurgery (P.Y.), Affiliated Hospital of North China University of Science and Technology, Tangshan; Department of Neurology (S.Z.), The Second Affiliated Hospital of Soochow University, Suzhou, China; and Department of Nutrition Science (M.R.F.), Purdue University, West Lafayette, IN.
M Edip GurolFrom the Department of Preventive Medicine (Yun Li), School of Public Health, North China University of Science and Technology, Tangshan; Department of Nutritional Sciences (Yun Li, X.G.), Pennsylvania State University, State College; Department of Nutrition (Yanping Li), Harvard T.H. Chan School of Public Health; Department of Neurology (M.E.G.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Neurology (Y. Liu) and Cardiology (J.S., S.W.), Kailuan General Hospital, North China University of Science and Technology; Department of Neurosurgery (P.Y.), Affiliated Hospital of North China University of Science and Technology, Tangshan; Department of Neurology (S.Z.), The Second Affiliated Hospital of Soochow University, Suzhou, China; and Department of Nutrition Science (M.R.F.), Purdue University, West Lafayette, IN.
Yesong LiuFrom the Department of Preventive Medicine (Yun Li), School of Public Health, North China University of Science and Technology, Tangshan; Department of Nutritional Sciences (Yun Li, X.G.), Pennsylvania State University, State College; Department of Nutrition (Yanping Li), Harvard T.H. Chan School of Public Health; Department of Neurology (M.E.G.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Neurology (Y. Liu) and Cardiology (J.S., S.W.), Kailuan General Hospital, North China University of Science and Technology; Department of Neurosurgery (P.Y.), Affiliated Hospital of North China University of Science and Technology, Tangshan; Department of Neurology (S.Z.), The Second Affiliated Hospital of Soochow University, Suzhou, China; and Department of Nutrition Science (M.R.F.), Purdue University, West Lafayette, IN.
Peng YangFrom the Department of Preventive Medicine (Yun Li), School of Public Health, North China University of Science and Technology, Tangshan; Department of Nutritional Sciences (Yun Li, X.G.), Pennsylvania State University, State College; Department of Nutrition (Yanping Li), Harvard T.H. Chan School of Public Health; Department of Neurology (M.E.G.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Neurology (Y. Liu) and Cardiology (J.S., S.W.), Kailuan General Hospital, North China University of Science and Technology; Department of Neurosurgery (P.Y.), Affiliated Hospital of North China University of Science and Technology, Tangshan; Department of Neurology (S.Z.), The Second Affiliated Hospital of Soochow University, Suzhou, China; and Department of Nutrition Science (M.R.F.), Purdue University, West Lafayette, IN.
Jihong ShiFrom the Department of Preventive Medicine (Yun Li), School of Public Health, North China University of Science and Technology, Tangshan; Department of Nutritional Sciences (Yun Li, X.G.), Pennsylvania State University, State College; Department of Nutrition (Yanping Li), Harvard T.H. Chan School of Public Health; Department of Neurology (M.E.G.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Neurology (Y. Liu) and Cardiology (J.S., S.W.), Kailuan General Hospital, North China University of Science and Technology; Department of Neurosurgery (P.Y.), Affiliated Hospital of North China University of Science and Technology, Tangshan; Department of Neurology (S.Z.), The Second Affiliated Hospital of Soochow University, Suzhou, China; and Department of Nutrition Science (M.R.F.), Purdue University, West Lafayette, IN.
Sheng ZhuangFrom the Department of Preventive Medicine (Yun Li), School of Public Health, North China University of Science and Technology, Tangshan; Department of Nutritional Sciences (Yun Li, X.G.), Pennsylvania State University, State College; Department of Nutrition (Yanping Li), Harvard T.H. Chan School of Public Health; Department of Neurology (M.E.G.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Neurology (Y. Liu) and Cardiology (J.S., S.W.), Kailuan General Hospital, North China University of Science and Technology; Department of Neurosurgery (P.Y.), Affiliated Hospital of North China University of Science and Technology, Tangshan; Department of Neurology (S.Z.), The Second Affiliated Hospital of Soochow University, Suzhou, China; and Department of Nutrition Science (M.R.F.), Purdue University, West Lafayette, IN.
Michele R FormanFrom the Department of Preventive Medicine (Yun Li), School of Public Health, North China University of Science and Technology, Tangshan; Department of Nutritional Sciences (Yun Li, X.G.), Pennsylvania State University, State College; Department of Nutrition (Yanping Li), Harvard T.H. Chan School of Public Health; Department of Neurology (M.E.G.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Neurology (Y. Liu) and Cardiology (J.S., S.W.), Kailuan General Hospital, North China University of Science and Technology; Department of Neurosurgery (P.Y.), Affiliated Hospital of North China University of Science and Technology, Tangshan; Department of Neurology (S.Z.), The Second Affiliated Hospital of Soochow University, Suzhou, China; and Department of Nutrition Science (M.R.F.), Purdue University, West Lafayette, IN.
Shouling WuFrom the Department of Preventive Medicine (Yun Li), School of Public Health, North China University of Science and Technology, Tangshan; Department of Nutritional Sciences (Yun Li, X.G.), Pennsylvania State University, State College; Department of Nutrition (Yanping Li), Harvard T.H. Chan School of Public Health; Department of Neurology (M.E.G.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Neurology (Y. Liu) and Cardiology (J.S., S.W.), Kailuan General Hospital, North China University of Science and Technology; Department of Neurosurgery (P.Y.), Affiliated Hospital of North China University of Science and Technology, Tangshan; Department of Neurology (S.Z.), The Second Affiliated Hospital of Soochow University, Suzhou, China; and Department of Nutrition Science (M.R.F.), Purdue University, West Lafayette, IN. xxg14@psu.edu drwusl@163.com.
Xiang GaoFrom the Department of Preventive Medicine (Yun Li), School of Public Health, North China University of Science and Technology, Tangshan; Department of Nutritional Sciences (Yun Li, X.G.), Pennsylvania State University, State College; Department of Nutrition (Yanping Li), Harvard T.H. Chan School of Public Health; Department of Neurology (M.E.G.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Neurology (Y. Liu) and Cardiology (J.S., S.W.), Kailuan General Hospital, North China University of Science and Technology; Department of Neurosurgery (P.Y.), Affiliated Hospital of North China University of Science and Technology, Tangshan; Department of Neurology (S.Z.), The Second Affiliated Hospital of Soochow University, Suzhou, China; and Department of Nutrition Science (M.R.F.), Purdue University, West Lafayette, IN. xxg14@psu.edu drwusl@163.com.
North China University of Science and Technology · CNPennsylvania State University · USSoochow University · CNHarvard University · USMassachusetts General Hospital · USSecond Affiliated Hospital of Soochow University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether in utero exposure to the Great Chinese Famine in 1959 to 1961 was associated with risk of intracerebral hemorrhage (ICH) in adulthood.
methodsIn this cohort analysis, we included 97,399 participants of the Kailuan Study who were free of cardiovascular disease and cancer at baseline (2006). Cases of incident ICH were confirmed by medical record review. We used the Cox proportional hazards model to calculate the hazard ratio (HR) and 95% confidence interval (CI) for ICH according to in utero famine exposure status.
resultsAmong 97,399 participants in the current analyses, 6.3% (n = 6,160) had been prenatally exposed to the Great Chinese Famine. During a median 9.0 years of follow-up (2006-2015), we identified 724 cases of incident ICH. After adjustment for potential confounders, the HR of ICH was 1.99 (95% CI 1.39-2.85) for in utero famine-exposed individuals vs individuals who were not exposed to the famine. When exposure to famine and severity of famine were examined jointly, the adjusted HR was 2.99 (95% CI 1.21-7.39) for in utero exposure to severe famine and 1.94 (95% CI 1.32-2.84) for in utero exposure to less severe famine relative to those without exposure to famine.
conclusionsIndividuals with in utero exposure to famine, especially those exposed to severe famine, were more likely to have ICH in midlife, highlighting the role of nutritional factors in susceptibility to this severe cerebral condition.
Indexed as
AdolescentAdultAgedAged, 80 and overCase-Control StudiesCerebral HemorrhageChinaCohort StudiesFamineFemaleHumansMaleMiddle AgedPregnancyPrenatal Exposure Delayed EffectsProportional Hazards Models
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