ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
M-Current Inhibition in Hippocampal Excitatory Neurons Triggers Intrinsic and Synaptic Homeostatic Responses at Different Temporal Scales.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Donepezil as a new therapeutic potential in KCNQ2- and KCNQ3-related autism.Frontiers in cellular neuroscience · 2024Article
- ACh Transfers: Homeostatic Plasticity of Cholinergic Synapses.Cellular and molecular neurobiology · 2023Review
- Structural plasticity of the axon initial segment in rat hippocampal granule cells following high frequency stimulation and LTP induction.Frontiers in neuroanatomy · 2023Article
- Homeostatic plasticity of axonal excitable sites in Alzheimer's disease.Frontiers in neuroscience · 2023Article
- Article
- Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study.Frontiers in neuroinformatics · 2022Article
- Evidence for Dual Activation ofInternational journal of molecular sciences · 2022Article
- Review
- Excitatory and inhibitory hippocampal neurons differ in their homeostatic adaptation to chronic M-channel modulation.Frontiers in molecular neuroscience · 2022Article
- Dyshomeostatic modulation of CaeLife · 2021Article
- Homeostatic Plasticity in Epilepsy.Frontiers in cellular neuroscience · 2020Article
- The Role of KFrontiers in physiology · 2020Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent alterations in neuronal activity elicit homeostatic plastic changes in synaptic transmission and/or intrinsic excitability. However, it is unknown whether these homeostatic processes operate in concert or at different temporal scales to maintain network activity around a set-point value. Here we show that chronic neuronal hyperactivity, induced by M-channel inhibition, triggered intrinsic and synaptic homeostatic plasticity at different timescales in cultured hippocampal pyramidal neurons from mice of either sex. Homeostatic changes of intrinsic excitability occurred at a fast timescale (1-4 h) and depended on ongoing spiking activity. This fast intrinsic adaptation included plastic changes in the threshold current and a distal relocation of FGF14, a protein physically bridging Na
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