ArticleProceedings of the National Academy of Sciences of the United States of America2020
The AMPK-PP2A axis in insect fat body is activated by 20-hydroxyecdysone to antagonize insulin/IGF signaling and restrict growth rate.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 75 citations in OpenAlex.
- A glucose-AMPK-FoxO-vestigial signaling axis underlies host sugar-mediated wing dimorphism in Laodelphax striatellus.Pest management science · 2026Article
- Beyond silkworms: translating molecular mechanisms of pesticide toxicity from Bombyx mori to lepidopteran pest management.Pest management science · 2026Review
- Genetic and Molecular Regulation of Ecdysone Biosynthesis During Insect Metamorphosis.Insects · 2026Review
- HcEcR Regulates Chitin Biosynthesis via 20E Signaling Rather Than Direct Transcriptional Activation in Hyphantria cunea Larvae.Archives of insect biochemistry and physiology · 2026Article
- SV2B is a crucial factor for early larval development in the silkworm, Bombyx mori.Insect science · 2026Article
- RNAi Power Targets in Insect Pests: Beyond Functional Validation to Biopesticide Development Potential.Plants (Basel, Switzerland) · 2026Review
- Convergent evolution of a conserved molecular network underlies parenting and sociality.Nature reviews. Genetics · 2026Review
- The Fat Body: Structure and Functions.Advances in experimental medicine and biology · 2026Review
- Histone acetylation homeodynamics navigates cell survival and apoptosis.Nature communications · 2025Article
- Silencing theInsects · 2025Article
- Remote control of AMPK via extracellular adenosine controls tissue growth.Nature cell biology · 2025Article
- Comparative transcriptomic and metabolomics analysis of ovary in Nilaparvata lugens after trehalase inhibition.BMC genomics · 2025Article
- Dysfunctional BCAA degradation triggers neuronal damage through disrupted AMPK-mitochondrial axis due to enhanced PP2Ac interaction.Communications biology · 2025Article
- Gene model for the ortholog ofmicroPublication biology · 2025Article
- Identification of Growth-Related GeneAnimals : an open access journal from MDPI · 2024Article
- Article
- A plant virus manipulates the long-winged morph of insect vectors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Long-term exposure to environmental concentration of dinotefuran disrupts ecdysis and sex ratio by dysregulating related gene expressions inFrontiers in endocrinology · 2024Article
- Research Progress on the Regulation of Autophagy and Apoptosis in Insects by Sterol Hormone 20-Hydroxyecdysone.Insects · 2023Review
- Adenosine Monophosphate-Activated Protein Kinase (AMPK) Phosphorylation Is Required for 20-Hydroxyecdysone Regulates Ecdysis inInternational journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In insects, 20-hydroxyecdysone (20E) limits the growth period by triggering developmental transitions; 20E also modulates the growth rate by antagonizing insulin/insulin-like growth factor signaling (IIS). Previous work has shown that 20E cross-talks with IIS, but the underlying molecular mechanisms are not fully understood. Here we found that, in both the silkworm
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.